High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients
المؤلفون المشاركون
Song, Qinjie
Yang, Xiaobing
Wu, Han
Liu, Ying
Chen, Xiaoli
Chen, Xi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The synaptic adhesion-like molecule (SALM) family is largely restricted to neural tissues and is involved in the regulation of neurite outgrowth and synapse formation.
However, the expression of SALM3 in gastric cancer (GC) and its clinical significance remain unclear.
The aim of the present study was to investigate the prognostic value of SALM3 in patients with GC.
Patients and Methods.
Expression of SALM3 was validated by tissue microarrays from 730 GC patients and statistically assessed for correlations with the clinical parameters and the prognosis of the patients.
The transcriptional and survival data of SALM3 in GC patients were also mined through the Oncomine and Kaplan-Meier Plotter databases.
Results.
SALM3 is overexpressed in the tumor cells and fibroblasts of clinical GC tissues, and a high level of SALM3 was significantly associated with tumor invasive characteristics.
Cox proportional hazards univariate and multivariate regression analyses revealed SALM3 expression in tumor cells or stroma as an independent prognostic factor in the overall survival rate of GC patients.
Furthermore, the survival of GC patients with high SALM3 expression in both tumor cells and fibroblasts was significantly poorer than that of the other groups.
Oncomine and Kaplan-Meier Plotter analyses further confirmed high levels of SALM3 expression in GC, and high levels of SALM3 expression were associated with shorter survival in patients.
Conclusion.
SALM3 may be a prognostic factor for GC and may potentially be a high-priority therapeutic target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Ying& Chen, Xiaoli& Chen, Xi& Yang, Xiaobing& Song, Qinjie& Wu, Han. 2019. High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Ying…[et al.]. High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Ying& Chen, Xiaoli& Chen, Xi& Yang, Xiaobing& Song, Qinjie& Wu, Han. High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر