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Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections
المؤلفون المشاركون
Labrador, Jorge
Hermida, Gerardo J.
Alvarez, Rodolfo
Anso, Victor
de Vicente, Pilar
Goñi, Mercedes
Gonzalez-Lopez, Tomas Jose
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-11
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Blast crisis (BC) continues to be the major challenge in the treatment of chronic myeloid leukemia.
Best results have been observed in a few patients who were successfully transplanted after returning to chronic phase.
Recent studies focus on the combination of chemotherapy with imatinib, but results remain unsatisfactory.
Since dasatinib induces deeper and faster responses, a reasonable strategy might be to combine it with chemotherapy, taking into account the alterations in T-cell response induced by dasatinib.
However, there are no published studies or case reports supporting the use of dasatinib as first line treatment for initial myeloid BC, and very little is known about infectious complications associated with this drug.
Based on this, we present the case of a patient diagnosed with an initial nonlymphoid phenotype BC, who achieved molecular response (MR4.5) with dasatinib and FLAG-IDA, but he suffered a pulmonary aspergillosis, CMV infection, and a CMV reactivation, prior to an allogeneic hematopoietic stem cell transplantation (HSCT).
In conclusion, dasatinib and FLAG-IDA is an effective therapy for initial BC.
However, a warning call is needed owing to the high risk of opportunistic infections, such as CMV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Labrador, Jorge& Hermida, Gerardo J.& Alvarez, Rodolfo& Anso, Victor& de Vicente, Pilar& Goñi, Mercedes…[et al.]. 2020. Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147856
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Labrador, Jorge…[et al.]. Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections. Case Reports in Hematology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147856
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Labrador, Jorge& Hermida, Gerardo J.& Alvarez, Rodolfo& Anso, Victor& de Vicente, Pilar& Goñi, Mercedes…[et al.]. Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147856
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147856
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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