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Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion
المؤلفون المشاركون
Wang, Chunyan
Luo, Xiaodan
Tan, Huo
Zheng, Runhui
Qin, Pengfei
Chen, Xiaobo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Double-expressor diffuse large B-cell lymphoma (DLBCL) with 17p deletion is an aggressive and refractory disease.
Immune checkpoint blockade and epigenetic drugs have been widely used, but the efficacy of different combined applications varied.
We report a case with “double-expressor” DLBCL treated with a combined regimen which consisted of programmed cell death protein 1 (PD-1) inhibitor, DNA methyltransferase inhibitor (DNMTi), and histone deacetylase inhibitor (HDACi).
A 50-year-old man presented with a 6-month history of hoarseness, and 10 days of progressive shortness of breath was diagnosed of DLBCL, stage IV.
The patient failed to respond to the 1st line (R-EPOCH: rituximab, etoposide, vincristine, cyclophosphamide, doxorubicin, and dexamethasone), 2nd line (R-EPOCH + lenalidomide + ibrutinib), and a 3rd line chemotherapy combined with PD-1 inhibitor (sintilimab), decitabine, and GDP (gemcitabine, DDP, and dexamethasone).
Surprisingly, patient’s condition was improved after treatment with PD-1 inhibitor in combination with DNMTi/HDACi.
Restaging PET revealed dramatically radiological response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Runhui& Chen, Xiaobo& Wang, Chunyan& Qin, Pengfei& Tan, Huo& Luo, Xiaodan. 2020. Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Runhui…[et al.]. Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Runhui& Chen, Xiaobo& Wang, Chunyan& Qin, Pengfei& Tan, Huo& Luo, Xiaodan. Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147864
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