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Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?
المؤلفون المشاركون
Cuartero, M.
Betbesé, A. J.
Núñez, K.
Baldirà, J.
Ordóñez Llanos, Jordi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To analyse the capacity of whole-blood NGAL (wbNGAL) to stratify AKI in critically ill patients with and without sepsis.
Methods.
Whole-blood NGAL was measured with a point-of-care device at admission and 48 hours later in patients admitted to a general ICU.
Patients were classified by the AKIN and KDIGO classifications at admission and 24 and 48 hours.
We performed an ROC curve analysis.
wbNGAL values at admission were compared in patients with sepsis and septic shock.
Results.
The study included 100 consecutively admitted patients (40 female) with mean age 59.1±17.8 years.
Thirty-three patients presented AKI at admission, and 10 more developed it in the next 48 h.
Eighteen patients had AKI stage 3, 14 of them at admission.
Nine patients required renal replacement therapy.
According to KDIGO at admission, wbNGAL values were 78 μg/L (60-187) in stage 0 (n=67), 263 μg/L (89-314) in stage 1 (n=8), 484 μg/L (333-708) in stage 2 (n=11), and 623 μg/L (231-911) in stage 3 (n=14), p=0.0001 for trend.
Ten patients did not complete 48 hours of study: 6 of 10 were discharged (initial wbNGAL 130 μg/L (60-514)) and 4 died (773 μg/L (311-1010)).
The AUROC curve of wbNGAL to predict AKI was 0.838 (95% confidence interval 0.76-0.92, p=0.0001), with optimal cut-off value of 178 μg/L (sensitivity 76.7%, specificity 78.9%, p<0.0001).
At admission, twenty-nine patients had sepsis, of whom 20 were in septic shock.
wbNGAL concentrations were 81 μg/L (60-187) in patients without sepsis, 481 (247-687) in those with sepsis, and 623.5 μg/L (361-798) in the subgroup of septic shock (p<0.0001).
Conclusions.
Whole-blood NGAL concentration at ICU admission was a good stratifier of AKI in critically ill patients.
However, wbNGAL concentrations were higher in septic patients irrespective of AKI occurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cuartero, M.& Betbesé, A. J.& Núñez, K.& Baldirà, J.& Ordóñez Llanos, Jordi. 2019. Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?. Disease Markers،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cuartero, M.…[et al.]. Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?. Disease Markers No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1147881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cuartero, M.& Betbesé, A. J.& Núñez, K.& Baldirà, J.& Ordóñez Llanos, Jordi. Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1147881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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