Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm
المؤلفون المشاركون
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A genome-wide association study (GWAS) identified that BET1L rs2280543 at chromosome 11p15.5 was a susceptibility loci of intracranial aneurysm (IA).
Long noncoding RNA H19, located in this region, was reported to play a crucial role in the formation of IA.
In this study, we aimed to examine whether BET1L rs2280543 and potentially functional polymorphisms in H19 influence the risk of IA.
A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls.
The BET1L rs2280543 and H19 polymorphisms were genotyped using the TaqMan assay.
The BET1L rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs.
CC, adjusted OR=1.43, 95% CI: 1.08-1.90, P=0.01; CT/TT vs.
CC, adjusted OR=1.48, 95% CI: 1.12-1.94, P=0.005; and T vs.
C, adjusted OR=1.44, 95% CI: 1.13-1.83, P=0.003).
Similarly, the H19 rs217727 TT genotype and T allele were associated with an increased risk of IA (TT vs.
CC, adjusted OR=1.90, 95% CI: 1.35-2.67, P<0.001; T vs.
C, adjusted OR=1.38, 95% CI: 1.16-1.64, P<0.001).
Combined analyses revealed that the rs2280543 CC-rs217727 CT/TT, rs2280543 CT/TT-rs2735971 GG, and rs217727 CT/TT-rs2735971 GG genotypes were related to the risk of IA.
Interaction analysis showed that the 3-loci model of rs2280543-rs217727-rs2839698 contributed to an increased risk of IA.
These findings suggest that the GWAS-discovered risk loci BET1L rs2280543 may increase IA susceptibility by interacting with lncRNA H19.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yi& Sima, Xiutian. 2019. Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yi& Sima, Xiutian. Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1148025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yi& Sima, Xiutian. Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر