Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis
المؤلفون المشاركون
Wang, Qifei
Tang, Chong
Jia, Junxiu
Zhang, Guangwu
Liu, Zheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Osteoporosis (OP) is a common polygenic disorder in the aging population, and several single nucleotide polymorphisms (SNPs) in the alpha-L-iduronidase (IDUA) gene and patched homolog 1 (PTCH1) gene regulate bone metabolism and affect bone mass.
The study aimed at investigating the relationships of rs3755955 and rs6831280 in the IDUA gene and rs28377268 in the PTCH1 gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP.
Materials and Methods.
A cohort of 328 unrelated senile osteoporosis (SOP) patients with or without osteoporotic fractures was recruited.
rs3755955, rs6831280, and rs28377268 polymorphisms were identified using SNaPshot technology.
BTM levels were determined by electrochemiluminescence (ECL).
Bone mineral densities (BMDs) at the lumbar spine (LS) and proximal femur sites were measured by dual-energy X-ray absorptiometry (DEXA) in all subjects.
The Hardy-Weinberg equilibrium (HWE) test was performed.
HWE P values and comparisons of genotype frequencies were estimated using the chi-square test.
Analysis of covariance (ANCOVA) adjusted for confounding factors was performed to investigate associations of SNPs with BMDs and BTMs in subgroups.
Results.
The chi-square test indicated that genotype distributions in the control group conformed to HWE (P>0.05).
The distributions of allele and genotype frequencies of rs6831280 between fracture and osteoporotic participants were significantly different (P-allele=0.002 and P-genotype=0.012, respectively).
Concerning rs6831280, ANCOVA found BMDs at LS 2-4 (L2-4) and total hip (TH) among the study subjects suffering from SOP with GA genotype were lower than in those carrying GG or AA (P-L2-4=0.004 and P-TH=0.027, respectively).
Conclusions.
IDUA rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Qifei& Tang, Chong& Jia, Junxiu& Zhang, Guangwu& Liu, Zheng. 2019. Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Qifei…[et al.]. Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1148030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Qifei& Tang, Chong& Jia, Junxiu& Zhang, Guangwu& Liu, Zheng. Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر