Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial Infarction
المؤلفون المشاركون
Kapłon-Cieślicka, Agnieszka
Budnik, Monika
Filipiak, Krzysztof J.
Opolski, Grzegorz
Tymińska, Agata
Ozierański, Krzysztof
Wancerz, Anna
Sypień, Piotr
Peller, Michał
Balsam, Paweł
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e′, and E/e′) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI).
Methods.
A prospective, observational study, BIOSTRAT (Biomarkers for Risk Stratification After STEMI), enrolled 117 patients between October 2014 and April 2017.
Gal-3 and sST2 serum collection and echocardiography were performed twice (during index hospitalization and on a control visit at one-year follow-up).
The primary endpoint was HF onset at one-year follow-up.
Secondary assessments included associations of biomarker concentration with echocardiographic indices of systolic and diastolic dysfunction at baseline and at one year.
Results.
Mean baseline concentrations of Gal-3 and sST2 (7.5 and 26.4 ng/mL, respectively) were significantly increased at one-year follow-up (8.5 ng/mL and p<0.001 and 31.4 ng/mL and p=0.001, respectively).
Patients who reached the primary endpoint (50 patients (48%)) had significantly higher baseline concentrations of both biomarkers and a higher Gal-3 level at one year compared to patients who did not.
Both Gal-3 and sST2 were predictors of the primary endpoint in univariate logistic regression analysis, but only Gal-3 remained significant in multivariate analysis.
There was no clear association between both biomarkers and echocardiographic parameters.
Conclusions.
Baseline, but not one-year, changes of Gal-3 and sST2 concentrations may be useful for risk stratification after STEMI.
However, only Gal-3 was the independent predictor of HF development at one-year observation.
This trial is registered with NCT03735719.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tymińska, Agata& Kapłon-Cieślicka, Agnieszka& Ozierański, Krzysztof& Budnik, Monika& Wancerz, Anna& Sypień, Piotr…[et al.]. 2019. Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial Infarction. Disease Markers،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tymińska, Agata…[et al.]. Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial Infarction. Disease Markers No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1148034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tymińska, Agata& Kapłon-Cieślicka, Agnieszka& Ozierański, Krzysztof& Budnik, Monika& Wancerz, Anna& Sypień, Piotr…[et al.]. Association of Galectin-3 and Soluble ST2, and Their Changes, with Echocardiographic Parameters and Development of Heart Failure after ST-Segment Elevation Myocardial Infarction. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر