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Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids
المؤلفون المشاركون
Zwolinska, Danuta
Pukajło-Marczyk, Agnieszka
Jakubowska, Anna
Bargenda-Lange, Agnieszka
Kiliś-Pstrusińska, Katarzyna
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Recurring nature of idiopathic nephrotic syndrome (INS) and steroid dependence imply a long-term treatment with glucocorticosteroids (GCSs), which increases the risk of bone metabolism disorders.
The search for new markers of that process is essential.
The aims of this study were to assess the concentrations of sclerostin (Scl) and fibroblast growth factor-23 (FGF-23) in the plasma of children with INS and compare Scl and FGF-23 to existing markers of bone metabolism, mainly parathyroid hormone (PTH).
The study involved 70 children, 50 with INS and 20 healthy children.
Patients with INS were divided into 4 groups depending on the number of relapses and applied therapy.
Significantly higher concentrations of FGF-23 and Scl were found in all patient groups with INS compared to the control group, and increase in the concentrations of examined parameters depending on the number of NS relapses was showed.
In patients from the group with numerous relapses, higher concentrations of FGF-23 and Scl in the relapse phase than those in the remission phase were found.
We observed positive correlation in these proteins with parathyroid hormone.
Positive correlation of FGF-23 and Scl in the examined group was noted.
Children having relapsing INS treated with steroids have higher levels of Scl and FGF-23 that can indicate the bone metabolism disorders.
The significance of these observations requires further research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pukajło-Marczyk, Agnieszka& Jakubowska, Anna& Bargenda-Lange, Agnieszka& Kiliś-Pstrusińska, Katarzyna& Zwolinska, Danuta. 2019. Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1148051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pukajło-Marczyk, Agnieszka…[et al.]. Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1148051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pukajło-Marczyk, Agnieszka& Jakubowska, Anna& Bargenda-Lange, Agnieszka& Kiliś-Pstrusińska, Katarzyna& Zwolinska, Danuta. Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1148051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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