Valuable Serum Markers in Pulmonary Alveolar Proteinosis
المؤلفون المشاركون
Xiao, Yonglong
Qiu, Xiaohua
Shi, Shenyun
Chen, Lulu
Zhao, Qi
Yan, Xin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP).
The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort.
Methods.
PAP patients from January 2010 to June 2018 were enrolled.
Hospital records were used as data sources.
The levels of various serum indicators were detected.
We evaluated the correlation between pulmonary function test results and clinical variables.
Results.
Diffusion capacity for carbon monoxide (DLCO) level was positively correlated with the level of high-density lipoprotein cholesterol (HDL-C) (P<0.05) in 122 patients of PAP at baseline.
The levels of HDL-C and DLCO significantly increased while carcinoembryonic antigen (CEA), CYFRA21-1, neuron-specific enolase (NSE), and lactic dehydrogenase (LDH) levels decreased six months after granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy between 14 patients with PAP.
Nevertheless, the increased DLCO was significantly correlated with decreased CEA (r=‐0.579, P=0.031) and CYFRA 21-1 (r=‐0.632, P=0.015).
In 10 PAP patients without GM-CSF inhalation therapy, HDL-C and DLCO significantly decreased while NSE and LDH levels increased after six months of follow-up.
The decreased DLCO was significantly correlated with increased LDH (r=‐0.694, P=0.026).
Conclusions.
Serum CEA, CYFRA21-1, and LDH are valuable serum markers for the evaluation of disease activity of PAP and may predict the response to treatment of PAP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Shenyun& Chen, Lulu& Qiu, Xiaohua& Zhao, Qi& Xiao, Yonglong& Yan, Xin. 2019. Valuable Serum Markers in Pulmonary Alveolar Proteinosis. Disease Markers،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Shenyun…[et al.]. Valuable Serum Markers in Pulmonary Alveolar Proteinosis. Disease Markers No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1148053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Shenyun& Chen, Lulu& Qiu, Xiaohua& Zhao, Qi& Xiao, Yonglong& Yan, Xin. Valuable Serum Markers in Pulmonary Alveolar Proteinosis. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر