Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma
المؤلفون المشاركون
Wu, Zheng
Du, Zhao-Qing
Lv, Yi
Wu, Rongqian
Bi, Jianbin
Zhang, Jia
Ren, Yifan
Ke, Mengyun
Zhang, Mei
Wang, Yawen
Zhang, Lin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Hepatectomy remains one of the most effective treatments for patients with hepatocellular carcinoma (HCC); however, it can lead to serious complications.
Irisin, a key regulator of energy metabolism, is secreted into the circulation by shedding of the extracellular portion of the fibronectin type III domain-containing 5 (FNDC5).
We have shown that irisin administration alleviates liver ischemia-reperfusion injury in mice.
However, the role of preoperative irisin levels in HCC patients who underwent hepatectomy remained unknown.
The purpose of this study was to determine how irisin expression changes in HCC and to explore the relationship between preoperative serum irisin levels and complications after hepatectomy.
Methods.
FNDC5/irisin expression data in HCC were extracted from The Cancer Genome Atlas (TCGA) dataset.
A total of 219 participants, including 102 healthy controls and 117 HCC patients, were recruited in this study.
All HCC patients underwent hepatectomy at the First Affiliated Hospital of the Xi’an Jiaotong University.
Preoperative serum irisin levels were measured by ELISA.
Postoperative complications were assessed using the comprehensive complication index (CCI) score.
The Pearson rank correlation coefficient was computed to assess the correlation between preoperative serum irisin levels and postoperative CCI scores.
Results.
In TCGA dataset, FNDC5/irisin expression was downregulated in HCC tissues (P<0.001).
Similarly, serum irisin levels were decreased in HCC patients (P<0.001).
Low preoperative serum irisin levels were significantly correlated with high CCI scores after hepatectomy.
Conclusions.
Irisin may be a novel serum biomarker in the diagnosis of HCC and a predictor of complications after hepatectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jia& Ke, Mengyun& Ren, Yifan& Bi, Jianbin& Du, Zhao-Qing& Zhang, Mei…[et al.]. 2019. Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease Markers،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1148079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jia…[et al.]. Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease Markers No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1148079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jia& Ke, Mengyun& Ren, Yifan& Bi, Jianbin& Du, Zhao-Qing& Zhang, Mei…[et al.]. Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1148079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر