Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo
المؤلفون المشاركون
Akakpo, Sefako
Kombaté, Koussaké
Mahamadou, Garba
Teclessou, Julienne
Dzidzinyo, Kossi
Diori, Adam Nouhou
Maneh, Nidain
Prince-Agbodjan, Sabin
Balo, Komi
Pitche, Palokinam
Mouhari-Toure, Abas
Tchangaï-Walla, Kissem
Saka, Bayaki
المصدر
Dermatology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae.
Patients and Method.
Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone.
Results.
Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo).
There were 113 women and 64 men, with an average age of 31.7±13.0 years (range: 5 to 80 years).
The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%).
HIV serology was positive in 68 (59.1%) of the 115 patients tested.
Sixty-four (52,5%) of the 122 patients, who had been examined by an ophthalmologist during the acute stage, had acute ocular involvement, which was mild in 27.9% of patients, moderate in 13.1%, and severe in 11.5%.
We recorded 17 deaths (i.e., three cases of SJS, 12 of TEN, and two of SJS/TEN overlap), including 11 cases of HIV infected patients.
Of the 160 SJS/TEN survivors, only 71 patients were assessed 6 months after hospital discharge.
Among them, forty-three (60.6%) patients had sequelae.
Concerning mucocutaneous sequelae, the main lesions were diffuse dyschromic macules (38.0% of patients) and ocular sequelae were dominated by decreased visual acuity (14.1% of patients).
In multivariate analysis, exposure to sulfadoxine (odds adjusted ratio = 5.95; 95%CI= [1.36-31.35]) and moderate (adjusted odds ratio = 5.85; 95%CI = [1.23-31.81]) or severe (adjusted odds ratio = 48.30; 95%CI = [6.25-1063.66]) ocular involvement at acute stage were associated with ocular sequelae.
Conclusion.
Ocular and mucocutaneous sequelae are common in SJS/TEN survivors.
Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saka, Bayaki& Akakpo, Sefako& Teclessou, Julienne& Mahamadou, Garba& Mouhari-Toure, Abas& Dzidzinyo, Kossi…[et al.]. 2019. Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo. Dermatology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saka, Bayaki…[et al.]. Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo. Dermatology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1148109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saka, Bayaki& Akakpo, Sefako& Teclessou, Julienne& Mahamadou, Garba& Mouhari-Toure, Abas& Dzidzinyo, Kossi…[et al.]. Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo. Dermatology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر