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False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review
المؤلفون المشاركون
Esperti, Shawn
Stoelting, Austen
Mangano, Andrew
Patel, Dveet
Sansbury, Jilian
Sherertz, Robert
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-14
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
A 70-year-old immunocompetent male in South Carolina was admitted secondary to altered mental status and headache without focal neurological deficits.
Head CT was negative.
Lumbar puncture (LP) revealed normal glucose, elevated protein, and lymphocytosis.
Opening pressure was 15 cm of H20.
CSF lateral flow assay was negative for cryptococcal antigen; CSF cultures showed no growth.
The patient rapidly improved on acyclovir and was diagnosed with presumed viral meningitis, as viral PCR and fungal culture were pending at time of discharge.
The patient’s condition quickly worsened and the patient returned one day later with right arm weakness and dysarthria.
Brain MRI revealed T2/flair signal abnormalities in the left frontal lobe with associated parenchymal enhancement.
Repeat LP revealed increasing white blood cell count with a worsening lymphocytosis and decreasing glucose, and opening pressure remained normal.
CSF fungal culture from the first admission grew Cryptococcus gattii, and repeated CSF cryptococcal antigen and culture returned positive.
The patient was started on IV steroids, induction Amphotericin and Fluconazole, followed by maintenance oral Fluconazole.
The patient’s clinical course was complicated by a brainstem lacunar infarction, which led to demise.
We present this case of Cryptococcus gattii meningoencephalitis to highlight the risk factors, characteristics, and challenges in diagnosis and treatment of an emerging disease in the Southeastern United States.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esperti, Shawn& Stoelting, Austen& Mangano, Andrew& Patel, Dveet& Sansbury, Jilian& Sherertz, Robert. 2020. False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review. Case Reports in Infectious Diseases،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148231
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esperti, Shawn…[et al.]. False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review. Case Reports in Infectious Diseases No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148231
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esperti, Shawn& Stoelting, Austen& Mangano, Andrew& Patel, Dveet& Sansbury, Jilian& Sherertz, Robert. False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review. Case Reports in Infectious Diseases. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148231
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148231
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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