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Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury
المؤلفون المشاركون
Ye, Miao-yong
Zhao, Fan
Ma, Ke
Zhou, Kang
Huang, Wen-Jie
Ma, Yin-feng
Zhao, Jian-feng
Fu, Hui-ying
Xu, Zeng-bao
Lv, Bo-dong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
HongJing I (HJI), a traditional Chinese herbal formula, has been confirmed to be effective for the clinical treatment of erectile dysfunction (ED).
However, the mechanism of action of HJI remains unclear.
Here, we aimed to investigate the effect and underlying mechanisms of HJI against ED in a rat model of bilateral cavernous nerve injury (BCNI).
Rats were divided into five groups: normal control (NC), BCNI-induced ED model (M), M + low-dose HJI (HL), M + medium-dose HJI (HM), and M + high-dose HJI (HH).
All groups were treated with normal saline or the relevant drug for 28 consecutive days after inducing BCNI-ED.
At the end of the treatment period, the intracavernous pressure (ICP) was recorded, and histological examination was conducted using Masson’s trichrome staining.
Immunofluorescence staining and western blotting were applied to detect the changes in fibrosis protein and Ras homolog A (RhoA), Rho-associated protein kinase 1 (ROCK1), and ROCK2 expression.
We found that HJI effectively improved the ICP in the treatment groups.
In addition, RhoA, ROCK1, and ROCK2 expression levels were increased upon BCNI-ED induction, and HJI successfully inhibited cavernosum fibrosis and the activation of RhoA/ROCK2 signaling.
Overall, these results suggest that the effects of HJI in attenuating ED may be caused, at least in part, by the suppression of RhoA/ROCK2 signaling and alleviation of fibrosis.
However, the precise mechanism surrounding this requires further investigation in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Miao-yong& Zhao, Fan& Ma, Ke& Zhou, Kang& Huang, Wen-Jie& Ma, Yin-feng…[et al.]. 2019. Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148399
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Miao-yong…[et al.]. Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1148399
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Miao-yong& Zhao, Fan& Ma, Ke& Zhou, Kang& Huang, Wen-Jie& Ma, Yin-feng…[et al.]. Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148399
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148399
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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