Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels
المؤلفون المشاركون
Zhang, Yunpeng
Gao, Chao
Chen, Danmei
Wang, Cuiting
Chen, Long
Zhang, Yaodong
Li, Bing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In addition to abnormalities of motor and posture, children with cerebral palsy (CP) often have intellectual disability.
As a complementary and alternative traditional Chinese medicine (TCM) therapy, Chinese Tuina massage, also called Tuina in China, has been widely applied in clinical treatment for CP in China for a long time.
However, the molecular basis for this still remains largely unknown.
Recently, DNA hydroxymethylation has been shown to be sensitive to environment and plays critical roles in some neurological disorders, whereas the research focusing on the relationship between 5 hmC and Tuina therapy for cerebral palsy is deficient.
In our study, we first observed that Tuina improved learning and memory functions of hypoxic-ischemic (HI) rat pups.
Meanwhile, 5 hmC level of the temporal lobe cortex in the HI neonatal rat model is decreased significantly compared to that of the rats in control and Tuina groups.
Then, we used the hMeDIP-Seq method to explore whether and how DNA hydroxymethylation is involved in Tuina therapy for cerebral palsy.
Genomic annotation of DhMRs of HI group’s hypo-hydroxymethylation to genes revealed enrichment in multiple neurodevelopmental signaling pathways.
Moreover, we found the depletion of 5 hmC modifications in genes associated with neuronal development was accompanied by reduced mRNA levels of these genes.
Taken together, our results indicate that Tuina may regulate the expression of neurodevelopment-related genes by changing the status of DNA hydroxymethylation, thereby improving learning and memory functions of cerebral palsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yunpeng& Gao, Chao& Chen, Danmei& Wang, Cuiting& Chen, Long& Zhang, Yaodong…[et al.]. 2019. Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148468
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yunpeng…[et al.]. Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1148468
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yunpeng& Gao, Chao& Chen, Danmei& Wang, Cuiting& Chen, Long& Zhang, Yaodong…[et al.]. Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148468
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148468
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر