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Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature
المؤلفون المشاركون
Jayakrishnan, Thejus T.
Shah, Deep
Mewawalla, Prerna
Kamran, Amir
Guha, Aritra
Salman Faisal, Muhammad
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Senile systemic amyloidosis is a multisystem disease where wild-type insoluble transthyretin (ATTRwt) protein gets deposited in the tissues leading to organ dysfunction.
Methodology.
We present the case of a patient who presented with hematuria and bladder involvement by ATTRwt amyloidosis who ultimately died of multiorgan failure.
Results.
The patient was an 82-year-old white male with a history of ischemic cardiomyopathy (ejection fraction (EF): 20–25%), chronic atrial fibrillation, chronic kidney disease (CKD), and carpal tunnel syndrome who presented with acute hematuria, urinary retention, and progressive fatigue.
He underwent cystoscopy and bladder biopsy which was positive on congo-red stain diagnostic for amyloidosis.
Echocardiogram demonstrated worsening of EF to 10–15% and concentric left ventricle hypertrophy.
MRI was not performed due to underlying CKD.
His condition deteriorated during the hospital stay, and he developed cardiogenic shock and progressive liver dysfunction.
Infectious workup was negative.
Meanwhile, the biochemical investigations (serum protein electrophoresis, immunofixation, and urine kappa/lambda chains) ruled out plasma cell dyscrasias.
Mass spectrometry analysis of the bladder biopsy specimen confirmed wild-type transthyretin (ATTRwt) amyloidosis consistent with senile systemic amyloidosis.
Due to patients’ extremely poor prognosis, his family wished to focus on patient’s comfort-oriented measures only, and patient passed away shortly thereafter.
Conclusion.
Senile systemic amyloidosis can rarely present in an atypical fashion such as hematuria.
The treatment options are limited in this disease process.
Novel therapies are in the early phases of development.
Concern also exists that in patients with multiple comorbidities, this entity is under recognized until the more advanced stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jayakrishnan, Thejus T.& Kamran, Amir& Shah, Deep& Guha, Aritra& Salman Faisal, Muhammad& Mewawalla, Prerna. 2020. Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature. Case Reports in Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jayakrishnan, Thejus T.…[et al.]. Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature. Case Reports in Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1148533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jayakrishnan, Thejus T.& Kamran, Amir& Shah, Deep& Guha, Aritra& Salman Faisal, Muhammad& Mewawalla, Prerna. Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature. Case Reports in Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1148533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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