SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose DeprivationReoxygenation Injury in HT22 Cells
المؤلفون المشاركون
Jia, Ji
Wang, Yuqing
Zhang, Yuanyuan
Yang, Liang
Yuan, Jin
Yang, Shuai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Curcumin (Cur) induces neuroprotection against brain ischemic injury; however, the mechanism is still obscure.
The aim of this study is to explore the potential neuroprotective mechanism of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells and investigate whether type-2 superoxide dismutase (SOD2) is involved in the curcumin-induced protection.
In the present study, HT22 neuronal cells were treated with 3 h OGD plus 24 h reoxygenation to mimic ischemia/reperfusion injury.
Compared with the normal cultured control group, OGD/R treatment reduced cell viability and SOD2 expression, decreased mitochondrial membrane potential (MMP) and mitochondrial complex I activity, damaged cell morphology, and increased lactic dehydrogenase (LDH) release, cell apoptosis, intracellular reactive oxygen species (ROS), and mitochondrial superoxide (P<0.05).
Meanwhile, coadministration of 100 ng/ml curcumin reduced the cell injury and apoptosis, inhibited intracellular ROS and mitochondrial superoxide accumulation, and ameliorated intracellular SOD2, cell morphology, MMP, and mitochondrial complex I activity.
Downregulating the SOD2 expression by using siRNA, however, significantly reversed the curcumin-induced cytoprotection (P<0.05).
These findings indicated that curcumin induces protection against OGD/R injury in HT22 cells, and SOD2 protein may mediate the protection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yuqing& Zhang, Yuanyuan& Yang, Liang& Yuan, Jin& Jia, Ji& Yang, Shuai. 2019. SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose DeprivationReoxygenation Injury in HT22 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yuqing…[et al.]. SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose DeprivationReoxygenation Injury in HT22 Cells. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1148841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yuqing& Zhang, Yuanyuan& Yang, Liang& Yuan, Jin& Jia, Ji& Yang, Shuai. SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose DeprivationReoxygenation Injury in HT22 Cells. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر