Active Ingredients and Action Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis
المؤلفون المشاركون
Wu, Zhongdao
Sze, Daniel Man-yuen
Zhang, Qianru
Hu, Yuanjia
Li, Guangyao
Zhou, Yuan
Liu, Chao
Wang, Zihao
Yu, Hua
Chan, Ging
Su, Shi-Bing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background and Aim.
The progression of liver fibrosis in chronic hepatitis B (CHB) patients is currently insufficiently controlled worldwide.
The Yi Guan Jian decoction (YGJD) has been widely used in the treatment of liver fibrosis in CHB cases.
Although animal studies have reported the antifibrotic effects of the decoction, the active ingredients of the YGJD remain unknown.
This study aimed at identifying the potential active ingredients and exploring the mechanisms of action (MOA) of the decoction when treating CHB patients with fibrosis.
Methods.
Using data mining techniques and a structural clustering analysis, the potential active ingredients were determined.
A network analysis of the differentially expressed genes was conducted to identify the potential targets.
Selected compounds were docked to the potential targets for the compound-target interaction simulation.
In vitro validation, including a cell proliferation assay and Western blot analysis, was conducted to evaluate the prediction results.
Results.
In the microarray data, 224 differentially expressed genes related to liver fibrosis were considered to be potential targets.
Thirty active ingredients of the YGJD and 15 main targets and relevant pathways were identified.
Among them, two active ingredients, methylophiopogonone A and 8-geranyloxypsoralen, were validated as exhibiting antifibrotic effects on hepatic stellate cells.
Conclusions.
We identified the potential active ingredients of the YGJD and proposed the possible explanation for the MOA in the treatment of CHB patients with liver fibrosis.
Moreover, this study provides a methodological reference for the systematic investigation of the bioactive compounds and related MOA of a traditional Chinese medicine formula in a clinical context.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Guangyao& Zhou, Yuan& Sze, Daniel Man-yuen& Liu, Chao& Zhang, Qianru& Wang, Zihao…[et al.]. 2019. Active Ingredients and Action Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1148924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Guangyao…[et al.]. Active Ingredients and Action Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1148924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Guangyao& Zhou, Yuan& Sze, Daniel Man-yuen& Liu, Chao& Zhang, Qianru& Wang, Zihao…[et al.]. Active Ingredients and Action Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1148924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148924
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر