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Plasmacytoid Urothelial Carcinoma of the Urinary Bladder Metastatic to the Duodenum: A Case Report—Diagnostic Relevance of GATA3 Immunohistochemistry
المؤلف
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a rare and aggressive subtype of urothelial carcinoma.
Its deceptive morphology is characterized by a discohesive growth of cells with plasmacytoid morphology.
Since this tumor might be confused with plasmacytoma, lymphoma, or carcinoma variants, appropriate diagnosis in small biopsy samples could be challenging.
This study reports the case of a 53-year-old man who presented with frequent nocturnal urgency, without hematuria.
A transurethral bladder and a prostate resection specimen displayed infiltration of neoplastic cells in a spray-like discohesive pattern with occasional formation of small irregular nests and cord-like arrangements.
The basic morphology of the tumor cells was plasmacytoid, with eccentric nuclei and eosinophilic cytoplasm.
Tumor cells grew through the lamina muscularis mucosae, with splintering of the bladder wall musculature and infiltration of prostatic tissue.
They displayed strong and diffuse nuclear reactivity for p53 and GATA3.
Eight months after surgery, the patient experienced upper abdominal discomfort.
A duodenal biopsy showed infiltration of plasmacytoid atypical cells strongly immunoreactive for GATA3, consistent with the previously diagnosed PUC.
The patient died eleven months after the primary diagnosis of his PUC of tumor cachexia losing about 50% of his original body weight, furthermore, with ascites and intraperitoneal tumor spread.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brustmann, Hermann. 2017. Plasmacytoid Urothelial Carcinoma of the Urinary Bladder Metastatic to the Duodenum: A Case Report—Diagnostic Relevance of GATA3 Immunohistochemistry. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1148962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brustmann, Hermann. Plasmacytoid Urothelial Carcinoma of the Urinary Bladder Metastatic to the Duodenum: A Case Report—Diagnostic Relevance of GATA3 Immunohistochemistry. Case Reports in Pathology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1148962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brustmann, Hermann. Plasmacytoid Urothelial Carcinoma of the Urinary Bladder Metastatic to the Duodenum: A Case Report—Diagnostic Relevance of GATA3 Immunohistochemistry. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1148962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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