Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis
المؤلفون المشاركون
Tao, Yueying
Tian, Kunming
Chen, Ji
Tan, Danfeng
Liu, Yan
Xiong, Yongai
Chen, Zehui
Tian, Yingbiao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
This study aims to predict the active ingredients, potential targets, signaling pathways and investigate the “ingredient-target-pathway” mechanisms involved in the pharmacological action of Danshiliuhao Granule (DSLHG) on liver fibrosis.
Pharmacodynamics studies on rats with liver fibrosis showed that DSLHG generated an obvious anti-liver fibrosis action.
On this basis, we explored the possible mechanisms underlying its antifibrosis effect using network pharmacology approach.
Information about compounds of herbs in DSLHG was collected from TCMSP public database and literature.
Furthermore, the oral bioavailability (OB) and drug-likeness (DL) were screened according to ADME features.
Compounds with OB≥30% and DL≥0.18 were selected as active ingredients.
Then, the potential targets of the active compounds were predicted by pharmacophore mapping approach and mapped with the target genes of the specific disease.
The compound-target network and Protein-Protein Interaction (PPI) network were built by Cytoscape software.
The core targets were selected by degree values.
Furthermore, GO biological process analysis and KEGG pathway enrichment analysis were carried out to investigate the possible mechanisms involved in the anti-hepatic fibrosis effect of DSLHG.
The predicted results showed that there were 108 main active components in the DSLHG formula.
Moreover, there were 192 potential targets regulated by DSLHG, of which 86 were related to liver fibrosis, including AKT1, EGFR, and IGF1R.
Mechanistically, the anti-liver fibrosis effect of DSLHG was exerted by interfering with 47 signaling pathways, such as PI3K-Akt, FoxO signaling pathway, and Ras signaling pathway.
Network analysis showed that DSLHG could generate the antifibrosis action by affecting multiple targets and multiple pathways, which reflects the multicomponent, multitarget, and multichannel characteristics of traditional Chinese medicine and provides novel basis to clarify the mechanisms of anti-liver fibrosis of DSLHG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tao, Yueying& Tian, Kunming& Chen, Ji& Tan, Danfeng& Liu, Yan& Xiong, Yongai…[et al.]. 2019. Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tao, Yueying…[et al.]. Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1148999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tao, Yueying& Tian, Kunming& Chen, Ji& Tan, Danfeng& Liu, Yan& Xiong, Yongai…[et al.]. Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1148999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1148999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر