Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition
المؤلفون المشاركون
Khan, Alisha
Dhamoon, Amit
Hingre, Jonathan
المصدر
Case Reports in Neurological Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Manganese accumulation in the central nervous system creates clinical symptoms of cognitive dysfunction, behavioral changes, and movement disorders resembling Parkinson’s disease.
Radiographic features of this rare clinical entity include symmetric T1 hyperintensities in the bilateral globus pallidi, with corresponding hypointensities on T2-weighted images.
Total parenteral nutrition (TPN) is an increasingly used potentially lifesaving therapy for patients who cannot tolerate enteral nutrition.
However, when used over a period of several weeks to months, its associated risks and complications carry significant morbidity and mortality.
One of the more rare complications of TPN use is manganese toxicity.
We provided care for a 38-year-old female on chronic TPN who presented to the hospital with Parkinsonian features, confusion, falls, and lethargy.
MRI brain showed T1 hyperintensities in the bilateral globus pallidi, which were attributed to manganese toxicity from chronic TPN use.
Supporting evidence for this rare entity included decreased signal intensity in the bilateral globus pallidi on T2-weighted images and T1 hyperintensities in the substantia nigra.
With antifungal treatment and permanent cessation of TPN, her mentation and neurological symptoms began to improve within a week.
Repeat MRI brain performed one month after discontinuation of TPN revealed improvement of the T1 hyperintensities in the bilateral globus pallidi.
Our objective in presenting this case is to highlight manganese neurotoxicity as a rare complication of TPN in a patient without known hepatic dysfunction and to emphasize the importance of routinely monitoring patients for the possible adverse effects of chronic TPN.
Our case is among the handful of published cases in which a patient without known liver dysfunction, which is the primary organ responsible for manganese elimination from the body, developed manganese neurotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Alisha& Hingre, Jonathan& Dhamoon, Amit. 2020. Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition. Case Reports in Neurological Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Alisha…[et al.]. Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition. Case Reports in Neurological Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Alisha& Hingre, Jonathan& Dhamoon, Amit. Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition. Case Reports in Neurological Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر