A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease
المؤلفون المشاركون
Gao, Xiu-Mei
Wang, Xiaoying
Zhang, Zhaojian
Wang, Yu
Tan, Wangxiao
Wang, Siwei
Liu, Jinghua
Liu, Xiao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-19
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Objective.
Danshen, the root of Salvia miltiorrhiza Bunge, is a traditional herbal medicine in China, which has been used to treat irregular menstruation, cold hernia, and abdominal pain for thousands of years.
Danshen is frequently used in combination with drugs to treat cardiovascular diseases.
Clopidogrel is a commonly used drug for treating coronary heart disease, but clopidogrel resistance restricts its development.
Therefore, the clinical efficacy of Danshen combined with clopidogrel treats coronary heart disease and the relationship between Danshen and clopidogrel metabolism enzymes is suggested for future investigations.
Materials and Methods.
The information was collected by searching online databases, and the RevMan 5.3 software was used to perform meta-analysis.
Results.
Twenty-two articles, including 2587 patients, were enrolled after the evaluation.
Meta-analysis showed that Danshen combined with clopidogrel was more effective than clopidogrel alone in treating coronary heart disease by improving clinical curative effect, reducing the frequency of angina pectoris, improving electrocardiogram results, shortening the duration of angina pectoris, and easing adverse reactions.
Danshen inhibited carboxylesterase 1 and most enzyme of cytochrome P450, especially cytochrome P450 1A2, which may affect the metabolism of clopidogrel.
Conclusion.
Danshen combined with clopidogrel may compensate for individual differences of clopidogrel resistance among individuals in the treatment of coronary heart disease.
Meanwhile, the inhibitory effect of Danshen on cytochrome P450 and carboxylesterase 1 could be partly responsible for the synergistic and attenuating effects of Danshen combined with clopidogrel.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhaojian& Wang, Yu& Tan, Wangxiao& Wang, Siwei& Liu, Jinghua& Liu, Xiao…[et al.]. 2019. A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1149098
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhaojian…[et al.]. A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1149098
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhaojian& Wang, Yu& Tan, Wangxiao& Wang, Siwei& Liu, Jinghua& Liu, Xiao…[et al.]. A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1149098
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149098
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر