Implication of Topical Steroids in the Onset of Osteoporosis
المؤلفون المشاركون
Milyani, Asmaa Adel
Al-Agha, Abdulmoein Eid
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The systemic bioavailability of steroids has long been implicated as a cause for osteoporosis (OP); however, much less is known about the effect of topical steroids on bone homeostasis.
This is a case of an 11-year-old male who is a known case of generalised pustular psoriasis for 8-year duration with frequent exacerbations controlled with topical betamethasone dipropionate.
He presented with generalised progressive bone pain and positive history of bone fracture.
The diagnosis of OP was established on the results of DEXA, which were −2.7 SD and −2.4 SD for the lumbar spine and whole body, respectively.
Although the cutoff value is the same (<−2 SD) in children, the definition of OP is more reliant on the densitometry Z score, as opposed to adults, who are approached using the T score.
The element of psoriasis poses a risk for the development of OP due to the presence of a chronic inflammatory disease state that increases bone turnover.
Furthermore, the compromised skin barrier and associated vasodilation seen in psoriasis enhance the absorption of topically applied agents and increase their bioavailability.
Children are a targeted risk group as they are more vulnerable to the manifestation of systemic adverse affects of topically applied steroids as a result of their increased ratio of total surface area relative to their body weight and slower drug metabolism.
We recommend that children undergoing long-term topical steroid therapy be screened for OP with the consideration of instituting prophylactic treatment especially in those suffering from chronic inflammatory disease states.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Milyani, Asmaa Adel& Al-Agha, Abdulmoein Eid. 2018. Implication of Topical Steroids in the Onset of Osteoporosis. Case Reports in Pediatrics،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Milyani, Asmaa Adel& Al-Agha, Abdulmoein Eid. Implication of Topical Steroids in the Onset of Osteoporosis. Case Reports in Pediatrics No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1149106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Milyani, Asmaa Adel& Al-Agha, Abdulmoein Eid. Implication of Topical Steroids in the Onset of Osteoporosis. Case Reports in Pediatrics. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر