Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour
المؤلفون المشاركون
Ueno, Hiroshi
Okamoto, Motoi
Suemitsu, Shunsuke
Murakami, Shinji
Kitamura, Naoya
Wani, Kenta
Ishihara, Takeshi
Matsumoto, Yosuke
Shimada, Atsumi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
α-Pinene, an organic terpene compound found in coniferous trees, is used as a safe food additive and is contained in many essential oils.
Moreover, some studies have shown that α-pinene suppresses neuronal activity.
In this study, we investigated whether inhalation of α-pinene suppresses dizocilpine (MK-801-) induced schizophrenia-like behavioural abnormalities in mice.
Mice inhaled α-pinene 1 h before the first MK-801 injection.
Thirty minutes after MK-801 injection, the open field, spontaneous locomotor activity, elevated plus maze, Y-maze, tail suspension, hot plate, and grip strength tests were conducted as behavioural experiments.
Inhalation of α-pinene suppressed the activity of mice in the spontaneous locomotor activity test and although it did not suppress the MK-801-induced increased locomotor activity in the open field test, it remarkably decreased the time that the mice remained in the central area.
Inhalation of α-pinene suppressed the MK-801-induced increased total distance travelled in the Y-maze test, whereas it did not alter the MK-801-induced reduced threshold of antinociception in the hot plate test.
In the tail suspension and grip strength tests, there was no effect on mouse behaviour by administration of MK-801 and inhalation of α-pinene.
These results suggest that α-pinene acts to reduce MK-801-induced behavioural abnormalities resembling those seen in neuropsychiatric disorders.
Therefore, both medicinal plants and essential oils containing α-pinene may have potential for therapeutic treatment of schizophrenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ueno, Hiroshi& Shimada, Atsumi& Suemitsu, Shunsuke& Murakami, Shinji& Kitamura, Naoya& Wani, Kenta…[et al.]. 2019. Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ueno, Hiroshi…[et al.]. Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1149115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ueno, Hiroshi& Shimada, Atsumi& Suemitsu, Shunsuke& Murakami, Shinji& Kitamura, Naoya& Wani, Kenta…[et al.]. Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر