Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer
المؤلفون المشاركون
Moreno-Acosta, Pablo
Romero-Rojas, Alfredo
Vial, Nicolas
Huertas, Antonio
Acosta, Jinneth
Mayorga, Diana
Carrillo, Schyrly
Molano, Monica
Cotes, Martha
Casadiego, Camila
Vallard, Alexis
Magne, Nicolas
Gamboa, Oscar
المصدر
Case Reports in Obstetrics and Gynecology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer.
Our study focuses on the risk factors and tumour molecular changes in one patient.
First in 1986, she was diagnosed a preinvasive cervix lesion.
Then, 16 years later, she was diagnosed an invasive cervical cancer.
The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion.
Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1.
Finally, the Arg72Pro polymorphism was detected in TP53.
The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer.
As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreno-Acosta, Pablo& Romero-Rojas, Alfredo& Vial, Nicolas& Huertas, Antonio& Acosta, Jinneth& Mayorga, Diana…[et al.]. 2020. Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreno-Acosta, Pablo…[et al.]. Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreno-Acosta, Pablo& Romero-Rojas, Alfredo& Vial, Nicolas& Huertas, Antonio& Acosta, Jinneth& Mayorga, Diana…[et al.]. Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر