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Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract
المؤلفون المشاركون
Zúñiga-González, Guillermo M.
Morales-Velazquez, Gabriela
Lazalde-Ramos, Blanca Patricia
Ortiz-García, Yveth Marlene
Gutiérrez-Hernández, Rosalinda
Guerrero-Velazquez, Celia
Sánchez de la Rosa, Susana Vanessa
Zamora-Perez, Ana Lourdes
Gómez-Meda, Belinda Claudia
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Jatropha dioica is traditionally used owing to its antiviral, antifungal, and antimicrobial properties.
But, toxicological information regarding J.
dioica root total extract is currently limited.
The aim of this work was to evaluate in a rat model, the transplacental genotoxicity effect of J.
dioica aqueous root total extract.
Three different J.
dioica aqueous root total extract doses (60, 100, and 300 mg/kg) were administered orally to Wistar rats during 5 days through the pregnancy term (16–21 days).
Pregnant rats were sampled every 24 h during the last 6 days of gestation, and pubs were sampled at birth.
Genome damage in dams and their newborn pups transplacentally exposed to J.
dioica was evaluated by in vivo micronuclei assay.
We evaluated the frequency of micronucleated erythrocytes (MNE), micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) in peripheral blood samples from pups and MNPCE and PCE in pregnant rats.
No genotoxic effect was observed after oral administration of the three different doses of aqueous root total extract of J.
dioica in pregnant or in their newborn pubs, after transplacental exposure.
A significant decrease in PCE frequency was noted in samples from pubs of rats treated with the highest dose of J.
dioica extract.
The aqueous total root extract of J.
dioica at the highest dose tested in our research do have cytotoxic effect in pups transplacentally exposed to this plant extract.
Moreover, neither a genotoxic nor a cytotoxic effect was observed in pregnant rats.
In the present work, there was no evidence of genome damage in the rat model after transplacental exposure to J.
dioica aqueous root total extract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morales-Velazquez, Gabriela& Lazalde-Ramos, Blanca Patricia& Gómez-Meda, Belinda Claudia& Zúñiga-González, Guillermo M.& Ortiz-García, Yveth Marlene& Gutiérrez-Hernández, Rosalinda…[et al.]. 2019. Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morales-Velazquez, Gabriela…[et al.]. Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1149188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morales-Velazquez, Gabriela& Lazalde-Ramos, Blanca Patricia& Gómez-Meda, Belinda Claudia& Zúñiga-González, Guillermo M.& Ortiz-García, Yveth Marlene& Gutiérrez-Hernández, Rosalinda…[et al.]. Genome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extract. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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