Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy
المؤلفون المشاركون
Tian, Jing
Chen, Hui-hua
Zhang, Meng-yun
Chen, Hui-juan
Zhu, Ling-ling
Zhao, Pei
Zhang, Ting
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Danggui Shaoyao San (DSS), a traditional Chinese medicinal prescription, was widely used to reinforce earth to activate collaterals in ancient times.
Recently, many clinical studies found that DSS had a renoprotection.
In this study, we evaluated the effect of DSS on unilateral ureteral obstruction- (UUO-) induced renal fibrosis in rats and investigated the mechanisms underlying the effect.
Sprague Dawley (SD) rats were randomized to UUO or Sham operation.
After 1 day, the rats that underwent UUO were randomized to treatment for four experimental groups (n=10 each group): Sham, UUO only, UUO+ benazepril (Bena), and UUO+DSS.
After 4 weeks, we demonstrated that DSS significantly suppressed UUO-induced renal hypertrophy by gravimetric.
In addition, DSS obviously prevented UUO-induced disorder in renal structure and renal function by HE and biochemistry test.
We also found that DSS abrogated UUO-induced renal fibrosis by Masson’s staining and collagen volume fraction (CVF) analysis; this is consistent with the western blot analysis that showed DSS abrogated the UUO-induced enhanced TGF-β1 and weakened BMP-7.
Compared with the UUO only group, rats treated with DSS exhibited significant increase in vascular density, followed by decrease in hypoxia and HIF-1α protein level through western blot and immunofluorescence analysis.
Furthermore, we also determined proteins of autophagy and DSS enhanced autophagy to prevent the damage-induced by UUO.
Taken together, our findings demonstrated that DSS had a renoprotection effect in ameliorating renal fibrosis possibly via attenuating tissue hypoxia and regulating autophagy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Meng-yun& Chen, Hui-hua& Tian, Jing& Chen, Hui-juan& Zhu, Ling-ling& Zhao, Pei…[et al.]. 2019. Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Meng-yun…[et al.]. Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1149216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Meng-yun& Chen, Hui-hua& Tian, Jing& Chen, Hui-juan& Zhu, Ling-ling& Zhao, Pei…[et al.]. Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر