A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery
المؤلفون المشاركون
Murata, Yuka
Nagamata, Satoshi
Nakasuji, Yukiko
Yamanaka, Keitaro
Azumi, Maho
Washio, Keiichi
Shimizu, Maho
Takahashi, Ryosuke
Matsumoto, Kazuyo
Suzuki, Kaho
Deguchi, Masashi
Terai, Yoshito
Yamada, Hideto
المصدر
Case Reports in Obstetrics and Gynecology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare.
Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract.
We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib.
A 62-year-old woman referred to our hospital due to abdominal distension.
From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed.
The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin.
After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results.
Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma.
After the additional chemotherapy and a 6-month observation period, the tumor relapsed.
The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor.
Oral administration of olaparib was thus initiated.
Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months.
This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nagamata, Satoshi& Nakasuji, Yukiko& Yamanaka, Keitaro& Azumi, Maho& Washio, Keiichi& Shimizu, Maho…[et al.]. 2020. A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nagamata, Satoshi…[et al.]. A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nagamata, Satoshi& Nakasuji, Yukiko& Yamanaka, Keitaro& Azumi, Maho& Washio, Keiichi& Shimizu, Maho…[et al.]. A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر