Corrigendum to “A Case of Sporadic Creutzfeldt-Jakob Disease Presenting as Conversion Disorder”

الملخص EN

In the Introduction of the article titled “A Case of Sporadic Creutzfeldt-Jakob Disease Presenting as Conversion Disorder” [1], the text reading “Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disease caused by aggregation of misfolded prion proteins.

A prion, named by Prusiner [1], is a proteinaceous infectious agent.

It is abundant in healthy neurons as a soluble protein.

However, it can be converted to a β-pleated form, PrPSc (prion protein scrapie), which can form insoluble aggregates in the nervous tissue.

These are resistant to degradation by proteases, can convert soluble prion proteins to PrPSc, and are transmissible.

PrPSc deposition leads to cortical and subcortical loss in the absence of inflammation, causing small vacuoles and a spongiform appearance [2].

The distribution of spongiform changes in the brain likely leads to the diverse neurological and psychiatric manifestations associated with this condition.