Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage

المؤلفون المشاركون

Arai, Kazumori
Iwasaki, Tomohiro
Tsuchiya, Chinatsu
Sonoda, Akihiro

المصدر

Case Reports in Oncological Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-19

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Spread through air spaces (STAS) is a unique form of lung cancer progression associated with a worse prognosis.

However, the mechanisms underlying STAS and the associated proteins remain unclear.

Annexin A2 (ANX A2), which is a membrane-binding protein involved in cell adhesion, is known to promote cancer invasion.

In this report, we describe the immunohistochemical analysis of ANX A2 expression in an invasive mucinous adenocarcinoma (IMAC) resected from a 63-year-old man in whom the tumor cells had detached from the alveolar wall and exhibited STAS.

At the detachment site, we observed cytoplasmic ANX A2 positivity on the basal side and in the exfoliative gap, as well as reduced collagen IV positivity expression.

This biomarker pattern suggested an IMAC with gastric lineage.

We hypothesize that ANX A2 is secreted from the basal sides of tumor cells and induces tumor cell detachment by degrading the basement membrane.

A further comparison of this case with an IMAC with nongastric lineage suggested the following probabilities: (1) ANX A2 likely contributes to STAS in a manner that is dependent on its subcellular localization.

(2) Both the subcellular localization of ANX A2 and the detachment site depend on tumor cell characteristics, including the biomarker immunophenotype.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Arai, Kazumori& Iwasaki, Tomohiro& Tsuchiya, Chinatsu& Sonoda, Akihiro. 2020. Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1149345

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Arai, Kazumori…[et al.]. Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1149345

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Arai, Kazumori& Iwasaki, Tomohiro& Tsuchiya, Chinatsu& Sonoda, Akihiro. Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1149345

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1149345