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In Vitro Antiatherothrombotic Effects of Extracts from Berberis Vulgaris L., Teucrium Polium L., and Orthosiphon Stamineus Benth
المؤلفون المشاركون
Md Noor, Sabariah
Othman, Fauziah
Mohd Tohit, Eusni Rahayu
Mohd Nor, Nurul Huda
Razali, Rosniza
Ahmad Hassali, Hazlina
Hassan, Hadijah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Coronary artery disease is the leading cause of mortality and morbidity worldwide.
The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation.
The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure.
As a part of disease management, treatment options using anticoagulant and antiplatelet drugs can be applied with addition to lipid-lowering medication.
However, medicinal plants comprising antiatherothrombotic effects can be used as options to combat the disease rather than drug therapies with lesser adverse effects.
Therefore, the haematological effect of Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus Benth extracts was studied using in vitro model to prevent and to treat coronary atherothrombotic disease.
The aqueous, methanol, and polysaccharide extracts of B.
vulgaris, T.
polium, and O.
stamineus, respectively, were studied for their anticoagulant and antiplatelet effect on human whole blood.
Extracts were subjected to the prothrombin time (PT) and activated partial thromboplastin time (APTT) test for anticoagulant activity.
The antiplatelet activity was investigated using an electrical impedance method.
B.
vulgaris aqueous extract (BVAE), B.
vulgaris polysaccharide extract (BVPE), T.
polium aqueous extract (TPAE), and T.
polium polysaccharide extract (TPPE) significantly prolonged the coagulation time in a concentration-dependent manner (p<0.05).
The administration of BVAE demonstrated the most effective antiplatelet activity against platelet aggregation caused by arachidonic acid (AA) and collagen.
These antiplatelet activities may correspond to the presence of higher total phenolic compound, which thus inhibit the platelet aggregation activity.
In conclusion, these findings provide strong evidence on the antiatherothrombotic effect of BVAE and TPAE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohd Nor, Nurul Huda& Othman, Fauziah& Mohd Tohit, Eusni Rahayu& Md Noor, Sabariah& Razali, Rosniza& Ahmad Hassali, Hazlina…[et al.]. 2019. In Vitro Antiatherothrombotic Effects of Extracts from Berberis Vulgaris L., Teucrium Polium L., and Orthosiphon Stamineus Benth. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149358
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohd Nor, Nurul Huda…[et al.]. In Vitro Antiatherothrombotic Effects of Extracts from Berberis Vulgaris L., Teucrium Polium L., and Orthosiphon Stamineus Benth. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1149358
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohd Nor, Nurul Huda& Othman, Fauziah& Mohd Tohit, Eusni Rahayu& Md Noor, Sabariah& Razali, Rosniza& Ahmad Hassali, Hazlina…[et al.]. In Vitro Antiatherothrombotic Effects of Extracts from Berberis Vulgaris L., Teucrium Polium L., and Orthosiphon Stamineus Benth. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149358
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149358
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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