A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review
المؤلفون المشاركون
Omar, Islam
Alsaati, Hani
Waris, Ejaz
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Gastrointestinal stromal tumours are rare tumours of the gastrointestinal tract (GIT) accounting for 0.1%–3% of all gastrointestinal tumours.
The most common location is the stomach (55%) followed by the small bowel (31.8%), colon (6%), other various locations (5.5%), and the oesophagus (0.7%).
They may also occur in extraintestinal locations.
The signs and symptoms of GIST depend on the tumour’s location and size.
Gastrointestinal bleeding is one of the most common symptoms.
Other signs and symptoms include abdominal discomfort, pain or distention; intestinal obstruction, and weight loss.
The association between the development of GISTs and neurofibromatosis 1 (NF1) has been established.
NF1-associated GISTs tend to have a distinct phenotype, and the absence of KIT/PDGRFα mutations in turn has implications on further management when they do not respond well to imatinib treatment.
Here, we present one of the largest GISTs reported in the literature with a total volume of 25.3×20×14 cm+27.9×23×8 cm and an overall weight of 7.3 kg, which developed in a 43-year-old female patient with NF1 and was resected on an emergency basis due to the rapid deterioration and development of abdominal compartment syndrome.
Pathology assessment showed a malignant GIST composed of spindle cells with elongated nuclei with necrosis, marked pleomorphism and numerous giant cell.
The mitotic count was >15/50 HPF, Ki 67 was 80%, and the lymphovascular invasion was clear.
Immunohistochemistry investigations showed that Vimentin, CD117, and DOG1 were positive, while BCL-2 and CD99 were focal positives.
Pan-CK, S-100, CD34, Desmin, SMA, and HMB-45 were negatives.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Omar, Islam& Alsaati, Hani& Waris, Ejaz. 2020. A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1149435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Omar, Islam…[et al.]. A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1149435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Omar, Islam& Alsaati, Hani& Waris, Ejaz. A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1149435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر