Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages
المؤلفون المشاركون
Zhao, Yanling
Niu, Ming
Xiao, Xiao-he
Hao, Junjie
Hu, Huangwanyin
Liu, Jing
Wang, Xuan
Liu, Xiaoyi
Wang, Jiabo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Panax ginseng (PG) is a widely used functional food and herbal with immunoregulation activity.
Currently, immunoregulation studies of PG mainly focused on the specific actions of individual constituents.
However, the integral immunoregulation mechanisms of PG need further research.
In this study, an integrated metabolomics and network pharmacology approach were used to investigate it.
High-content screening was used to evaluate macrophage phagocytosis activity of PG.
Untargeted metabolomics profiling of murine macrophage cells with UHPLC-Q-TOF-MS and a multivariate data method were performed to discover the potential biomarkers and metabolic pathways.
Then, a macrophage phenotype related “ingredients-targets-metabolites” network of PG was constructed using network pharmacology for further research.
As a result, PG can significantly enhance macrophage phagocytosis of GFP-E.
coli.
A total of twenty potential biomarkers and ten main pathways for which levels changed markedly upon treatment were identified, including glycerophospholipid metabolism, glutathione metabolism, choline metabolism, and taurine metabolism.
Twenty compounds of PG associated with metabolomic changes were selected by the network pharmacology analysis, including ginsenoside Re, ginsenoside Rg1, frutinone A, and kaempferol.
The network pharmacology results also showed that PG can polarize macrophages to both M1 and M2 phenotype but may be prone to M2 phenotype.
In conclusion, our results indicated that PG may be prone to polarize macrophages to M2 phenotype by mainly regulating the glutathione and choline metabolism, which was related to twenty compounds of PG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hao, Junjie& Hu, Huangwanyin& Liu, Jing& Wang, Xuan& Liu, Xiaoyi& Wang, Jiabo…[et al.]. 2019. Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1149493
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hao, Junjie…[et al.]. Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1149493
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hao, Junjie& Hu, Huangwanyin& Liu, Jing& Wang, Xuan& Liu, Xiaoyi& Wang, Jiabo…[et al.]. Integrated Metabolomics and Network Pharmacology Study on Immunoregulation Mechanisms of Panax ginseng through Macrophages. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1149493
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149493
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر