Advanced Lung Adenocarcinoma Patient with ERBB2 Amplification Identified by Comprehensive Genomic Profiling Benefits from Trastuzumab
المؤلفون المشاركون
Tao, Chi-Wei
Chen, Shu-Jen
Lapke, Nina
Tan, Kien Thiam
Chen, Mei-Yin
Tseng, Ching-Min
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-02
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
For non-small-cell lung cancer (NSCLC) patients without established actionable alterations in genes such as EGFR or ALK, options for targeted therapy remain limited in clinical practice.
About 5% of lung adenocarcinoma patients have tumors with ERBB2 genetic alterations, with even fewer patients harboring ERBB2 amplification.
Currently, clinical trials mainly use IHC, FISH, or mutation testing to identify potential responders to ERBB2-targeting agents.
The use of next-generation sequencing (NGS) to detect ERBB2 alterations, including copy number variants, is rare.
In this study, we present an EGFR- and ALK-negative advanced NSCLC case for which we conducted comprehensive tumor genomic profiling to identify potentially actionable alterations.
The tumor harbored an ERBB2 amplification, and trastuzumab-based therapy resulted in an excellent response, with a necrotic regression of the patient’s lung lesion.
Although he developed brain metastasis four months after trastuzumab initiation, he survived for an additional period of eight months without local recurrence or other systemic metastasis.
This case report shows that the use of comprehensive genetic testing enables the identification of rare actionable alterations in NSCLC patients without other options for targeted treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tao, Chi-Wei& Chen, Mei-Yin& Tseng, Ching-Min& Lapke, Nina& Chen, Shu-Jen& Tan, Kien Thiam. 2020. Advanced Lung Adenocarcinoma Patient with ERBB2 Amplification Identified by Comprehensive Genomic Profiling Benefits from Trastuzumab. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tao, Chi-Wei…[et al.]. Advanced Lung Adenocarcinoma Patient with ERBB2 Amplification Identified by Comprehensive Genomic Profiling Benefits from Trastuzumab. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1149536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tao, Chi-Wei& Chen, Mei-Yin& Tseng, Ching-Min& Lapke, Nina& Chen, Shu-Jen& Tan, Kien Thiam. Advanced Lung Adenocarcinoma Patient with ERBB2 Amplification Identified by Comprehensive Genomic Profiling Benefits from Trastuzumab. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر