![](/images/graphics-bg.png)
The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish
المؤلفون المشاركون
Song, Jie
Feng, Liang
Zhong, Rongling
Chen, Ying
Ling, Jie
Xia, Zhi
Zhan, Yang
Sun, E.
Shi, Ziqi
Jia, Xiaobin
Wei, Yingjie
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Zebrafish is being increasingly used for metabolism and toxicity assessment.
The drugs consumed in zebrafish metabolism studies are far less than those used in rat studies.
In our study, zebrafish embryos were exposed to icariin, Baohuoside I (BI), Epimedin A (EA), Epimedin B (EB), Epimedin C (EC), Sagittatoside A (SA), Sagittatoside B (SB), and 2′′-O-rhamnosylicariside II (SC), respectively, to examine the toxicity and metabolic profiles of these flavonoids.
The order of toxicity was SC, SB > EC, SA > BI, icariin, EA, EB.
After 24 h exposure to SB and SC, the mortality of zebrafish larvae reached 100% and yolk sac swollen was obvious.
Both SC and SB caused severe hepatocellular vacuolization and liver cells degeneration in adult zebrafish after 15 consecutive days’ treatment.
The metabolic profiles of these flavonoids with trace amount were also monitored in larvae.
BI was the common metabolite shared by icariin, EA, EB, SA, and SB, via deglycosylation.
Both BI and SC remained as the prototype in the medium, suggesting that it is hard for BI and SC to cleave the rhamnose residue.
EC was metabolized into SC and BI in zebrafish, inferring that SC might be responsible for the toxicity observed in EC group.
The metabolites of icariin, EA, EB, EC, and BI in zebrafish larvae coincided with results from rats and intestinal flora.
These data support the use of this system as a surrogate in predicting metabolites and hepatotoxicity risk, especially for TCM compound with trace amount.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Rongling& Chen, Ying& Ling, Jie& Xia, Zhi& Zhan, Yang& Sun, E.…[et al.]. 2019. The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149565
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Rongling…[et al.]. The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1149565
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Rongling& Chen, Ying& Ling, Jie& Xia, Zhi& Zhan, Yang& Sun, E.…[et al.]. The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149565
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149565
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)