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Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation
المؤلفون المشاركون
Li, Bing
Yang, Meng
He, Gai-Li
Gao, Xu-Guang
Li, Le
Zhai, Wen-Sheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-18
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the efficacy and safety of traditional Chinese medicine in preventing kidney damage caused by Henoch-Schonlein Purpura (HSP) in Children by meta-analysis.
Methods.
We systematically searched the main Chinese and English electronic databases and collected randomized controlled trials of Chinese herbs in children with HSP until July 2018.
Then we used the bias risk assessment tool in Cochrane Handbook 5.
1.
0 to complete the risk assessment of the included studies.
We utilized STATA12.0 and RevMan 5.3 for meta-analysis and GRADE pro.
for quality evaluation of evidence.
Result.
(1) Meta-analysis: data from 39 studies, representing 3643 individuals, were included in the analysis.
Thirty-seven studies were treated with traditional Chinese medicine for clearing away heat and cooling blood, which were combined.
On this basis, subgroup analysis was conducted according to the bias risk of the original study.
It showed that Chinese herbs can significantly improve the treatment effect (OR: 4.31, 95% CI [3.34, 5.57], P < 0.01) and reduce the risk of renal damage (RR: 0.36; 95% CI [0.21, 0.61], P < 0.01) and the risk of recurrence (RR: 0.43, 95% CI [0.34, 0.54], P<0.01).
(2) Side effect: a total of 7 studies described adverse reactions, and 12 of 319 patients in therapy group had adverse events and 20 of 263 patients in control group.
(3) Publication bias: the bias risk Egger’s test for the incidence of kidney injury was P=0.572, the relapse rate Egger’s test was P=0.175, the efficiency was combined with the low-risk original study, and the bias risk Egger’s test was P=0.175.
There was not any significant publication bias based on the funnel plot and Egger’s test.
(4) GRADE evaluation: GRADE evaluation showed that the quality of evidence in the risk of renal damage and recurrence rate was moderate.
Conclusion.
Chinese medicine treatment can prevent the occurrence of renal damage in children with HSP and can reduce the recurrence rate, the incidence of adverse reactions, and the effect in terms of efficiency.
However, the quality of the included studies in the meta-analysis and the quality of the evidence of outcomes were not high; the clinical use of the evidence needs to be cautious.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Bing& Yang, Meng& He, Gai-Li& Gao, Xu-Guang& Li, Le& Zhai, Wen-Sheng. 2019. Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1149720
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Bing…[et al.]. Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1149720
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Bing& Yang, Meng& He, Gai-Li& Gao, Xu-Guang& Li, Le& Zhai, Wen-Sheng. Efficacy and Safety of Chinese Herbs for the Prevention of the Risk of Renal Damage in Henoch-Schonlein Purpura in Children: Meta-Analysis of Randomized Controlled Trials and GRADE Evaluation. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1149720
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149720
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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