Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression
المؤلفون المشاركون
Chu, Li
Ping, Xin
Qin, Shao-Kun
Liu, Shu-Ning
Lu, Ye
Zhao, Ya-Nan
Cao, Ya-Fei
Zhang, Yan-Hong
Zhang, Shao-Dan
Pei, Lin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-13
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Huazhuo Jiedu Shugan decoction (HJSD), a traditional Chinese medicine (TCM), has been used to treat epileptic seizures for many years.
Some ingredients in these herbs have been demonstrated to be effective for the treatment of brain damage caused by epilepsy.
Aim of the Study.
The object of the study is to determine the effects of HJSD on cognitive and emotional disorders in a rat model of epilepsy.
Materials and Methods.
After a predetermined time period, rats were intraperitoneally injected with pentylenetetrazol and observed in different phases of convulsions.
The cognitive and emotional changes in the epileptic rats were assessed using behavioral and immunohistochemical tests.
Results.
Compared with the epilepsy group, the seizure grade was reduced and seizure latency was prolonged following HJSD-H treatment (P<0.01).
Compared with the control group, the epilepsy group displayed marked worse performance on the animal behavior tests (P<0.05) and the HJSD-H group displayed improved behavioral performance (P<0.05).
After HJSD-H treatment, the expression of adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), cAMP-response element binding protein (CREB), and neuropeptide Y (NPY) immunoreactive cells markedly increased in the hippocampus, compared with that of the epilepsy group (P<0.05).
Conclusions.
The current results demonstrate that HJSD treatment in epileptic rats markedly inhibits epileptic seizures and improves cognitive and emotional disorders, which may be related to the regulation of AC-cAMP-CREB signaling and NPY expression in the hippocampus.
The effects of the HJSD treatment may provide a foundation for the use of HJSD as a prescription medicinal herb in the TCM for the treatment of epilepsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ping, Xin& Qin, Shao-Kun& Liu, Shu-Ning& Lu, Ye& Zhao, Ya-Nan& Cao, Ya-Fei…[et al.]. 2019. Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ping, Xin…[et al.]. Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ping, Xin& Qin, Shao-Kun& Liu, Shu-Ning& Lu, Ye& Zhao, Ya-Nan& Cao, Ya-Fei…[et al.]. Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر