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Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology
المؤلفون المشاركون
Meng, Ziqi
Liu, Xinkui
Wu, Jiarui
Zhou, Wei
Wang, Kaihuan
Jing, Zhiwei
Liu, Shuyu
Ni, Mengwei
Zhang, Xiaomeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Compound Kushen Injection (CKI) is a Chinese patent drug that shows good efficacy in treating lung cancer (LC).
However, its underlying mechanisms need to be further clarified.
Methods.
In this study, we adopted a network pharmacology method to gather compounds, predict targets, construct networks, and analyze biological functions and pathways.
Moreover, molecular docking simulation was employed to assess the binding potential of selected target-compound pairs.
Results.
Four networks were established, including the compound-putative target network, protein-protein interaction (PPI) network of LC targets, compound-LC target network, and herb-compound-target-pathway network.
Network analysis showed that 8 targets (CHRNA3, DRD2, PRKCA, CDK1, CDK2, CHRNA5, MMP1, and MMP9) may be the therapeutic targets of CKI in LC.
In addition, molecular docking simulation indicated that CHRNA3, DRD2, PRKCA, CDK1, CDK2, MMP1, and MMP9 had good binding activity with the corresponding compounds.
Furthermore, enrichment analysis indicated that CKI might exert a therapeutic role in LC by regulating some important pathways, namely, pathways in cancer, proteoglycans in cancer, PI3K-Akt signaling pathway, non-small-cell lung cancer, and small cell lung cancer.
Conclusions.
This study validated and predicted the mechanism of CKI in treating LC.
Additionally, this study provides a good foundation for further experimental studies and promotes the reasonable application of CKI in the clinical treatment of LC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Ziqi& Liu, Xinkui& Wu, Jiarui& Zhou, Wei& Wang, Kaihuan& Jing, Zhiwei…[et al.]. 2019. Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Ziqi…[et al.]. Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Ziqi& Liu, Xinkui& Wu, Jiarui& Zhou, Wei& Wang, Kaihuan& Jing, Zhiwei…[et al.]. Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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