Potential Antiglycation and Hypoglycaemic Effects of Toona ciliata M. Roem. and Schkuhria pinnata Lam. Thell. Crude Extracts in Differentiated C2C12 Cells
المؤلفون المشاركون
Mampuru, Leseilane
Mokgotho, Matlou Phineas
Mbazima, Vusi
Matsebatlela, T. M.
Bagla, V. P.
Beseni, Brian K.
Njanje, Idris
Poopedi, Kgomotso
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Medicinal plants have been identified as a feasible avenue for the development of new potent antidiabetic agents.
The phytoconstituent compositions of different Toona ciliata and Schkuhria pinnata extracts were determined and quantified using standard chemical methods after exhaustive extraction.
Thereafter, their antioxidant and antiglycation potentials were spectrophotometrically determined.
The cytotoxicity profiles of the extracts on C2C12 cells were determined using the MTT assay.
Toona ciliata methanol extract resulted in the highest percentage yield (20.83%) and high total phenols and flavonoids content in the methanol and acetone extracts compared to S.
pinnata extracts.
The acetone extract of T.
ciliata showed good activity in the DPPH scavenging and FRAP assays with EC50 values of 1.90 mg/ml and 5.26 mg/ml, respectively.
Arbutin’s antiglycation ability was outperformed by treatments with the methanol, acetone, and hexane extract of T.
ciliata which resulted in 2.49%, 2.79%, and 2.56% glycation, respectively.
The hexane extract of T.
ciliata was less toxic to C2C12 cells as compared to the other extracts with CC50 value of 402.16 μg/ml.
Only the hexane extract of S.
pinnata resulted in glucose utilisation of 28.56% which was higher than that of insulin (26.06%) after 6 hours and is therefore considered as the most potent extract with hypoglycaemic potential in this study.
Studies are ongoing aimed at identifying drug candidates in this extract that may be employed in the development of hypoglycaemic, antioxidant, and antiglycation agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Beseni, Brian K.& Matsebatlela, T. M.& Bagla, V. P.& Njanje, Idris& Poopedi, Kgomotso& Mbazima, Vusi…[et al.]. 2019. Potential Antiglycation and Hypoglycaemic Effects of Toona ciliata M. Roem. and Schkuhria pinnata Lam. Thell. Crude Extracts in Differentiated C2C12 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1150134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Beseni, Brian K.…[et al.]. Potential Antiglycation and Hypoglycaemic Effects of Toona ciliata M. Roem. and Schkuhria pinnata Lam. Thell. Crude Extracts in Differentiated C2C12 Cells. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1150134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Beseni, Brian K.& Matsebatlela, T. M.& Bagla, V. P.& Njanje, Idris& Poopedi, Kgomotso& Mbazima, Vusi…[et al.]. Potential Antiglycation and Hypoglycaemic Effects of Toona ciliata M. Roem. and Schkuhria pinnata Lam. Thell. Crude Extracts in Differentiated C2C12 Cells. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1150134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر