FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy
المؤلفون المشاركون
Song, Jie
Bi, Lei
Cao, Meng
Li, Lingchang
Wang, Haiyan
Qian, Jun
Wei, Guoli
Ding, Rong
Hu, Canhong
Fang, Dong
Jiang, Ziyu
Ma, Jun
Qin, Fengxia
Huang, Xiaofei
Huo, Jiege
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The traditional Chinese medicine decoction FuFangChangTai (FFCT) has been used in the therapy of colon cancer clinically, yielding alleviated toxicity and enhanced immunity.
In our previous study, FFCT exerted its antitumor activity not only by inducing apoptosis but also by activating autophagy to eliminate tumor cells.
However, its mechanism is not well understood.
The purpose of this study was to investigate the relationship between macrophages activation and FFCT-induced autophagy.
Results showed that FFCT could induce autophagy in colon cancer, as demonstrated by increased level of intracellular autophagy marker LC3 II in CT26.WT cells by fluorescence microscope and western blot assay.
FFCT also facilitated numbers of vesicular bodies with bilayer membrane in CT26.WT cells, which were indicative of autophagosomes formation.
Autophagosomes secreted by FFCT-treated CT26.WT cells can activate M1 type macrophages, accompanied with increased expression of costimulatory molecules CD86 and CD40 on the surface of RAW264.7 cells, and more inflammatory cytokines secretion, such as TNF-α, IL-6, MCP-1, and IL-1β.
mRNA expressions of M2 macrophages markers, such as IL-10, CD206, Arg-1, and FIZZ-1, were downregulated.
And this process helps regulate the polarization of macrophages and promote the immune response.
These findings support a mechanism of FFCT-induced autophagy and provide novel evidence demonstrating that macrophages are involved in FFCT-induced autophagy progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Lingchang& Wang, Haiyan& Qian, Jun& Wei, Guoli& Ding, Rong& Hu, Canhong…[et al.]. 2019. FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150192
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Lingchang…[et al.]. FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1150192
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Lingchang& Wang, Haiyan& Qian, Jun& Wei, Guoli& Ding, Rong& Hu, Canhong…[et al.]. FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150192
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150192
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر