In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera
المؤلفون المشاركون
López, Zaira
Femenia, Antoni
Núñez-Jinez, Gabriela
Salazar Zúñiga, Michelle N.
Cano, M. Eduardo
Espino, Teresa
Knauth, Peter
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Food industries typically use Aloe vera as concentrated (100× to 200×) and dried powders in their final products.
These powders are obtained by extrusion of Aloe inner leaf gel (ILG) or Aloe whole leaf (WLP); the juice is filtered through diatomaceous earth and activated carbon before spray drying at temperatures below 70 °C.
In another process, Aloe inner leaf gel was dried at ~80 °C and mashed to a powder rich in high molecular weight fibres and soluble polysaccharides (ILF).
In contrast to ILG and WLP, the ILF sample was cytotoxic for the human intestinal cell line Caco-2 (CC50 = 1 g/l), even at concentrations below the recommended dose for human consumption.
At lower concentrations (250 mg/l) with LPS challenged macrophage-like THP-1 cells decreased by 40% the release of the anti-inflammatory cytokine IL-10, whereas the release of the proinflammatory cytokine IL-1β increased by 35% (compared to untreated but challenged macrophage-like THP-1 cells).
Unexpectedly, under the same conditions, the less cytotoxic ILG and WLP, both samples with a lower fibre content, significantly increased (up to 2.4 times) the release of IL-10, while the concentration of IL-1β remained unaltered and of TNFα decreased by 35%.
Even more interesting is that a treatment of the ILF sample with activated carbon reduced its cytotoxicity and increased the IL-10 release (3.1 times).
Based on these results, we suggest applying an activated carbon treatment on Aloe-starting products, which have high fibre content and have received high temperature treatment, in order to reduce their cytotoxicity and improve their immunomodulatory properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López, Zaira& Femenia, Antoni& Núñez-Jinez, Gabriela& Salazar Zúñiga, Michelle N.& Cano, M. Eduardo& Espino, Teresa…[et al.]. 2019. In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150305
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López, Zaira…[et al.]. In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150305
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López, Zaira& Femenia, Antoni& Núñez-Jinez, Gabriela& Salazar Zúñiga, Michelle N.& Cano, M. Eduardo& Espino, Teresa…[et al.]. In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150305
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150305
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر