Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL6 Mice
المؤلفون المشاركون
Seo, Yun-Soo
Lim, Hye-Sun
Choi, Goya
Ryu, Seung Mok
Moon, Byeong Cheol
Kim, Joong-Sun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Mantidis Ootheca (MO), described as the ootheca of Hierodula patellifera Serville, 1839, Tenodera angustipennis (Saussure, 1869), or Statilia maculate (Thunberg, 1784) in Korean Herbal Pharmacopoeia, is an important herbal material that has been traditionally used for treating several medical conditions including renal failure, spermatorrhea, and pediatric enuresis in Korea.
Objective.
The present study investigated the potential subacute toxicity of MO water extract during a 2-week repeated oral administration of doses of 0, 50, 150, or 450 mg/kg/day to C57BL/6 male mice by gavage.
Methods.
The following parameters were examined during the study period: mortality, clinical signs, body weight, hematology, serum biochemistry, gross findings, organ weight, and histopathology.
All the mice were euthanized at the end of the treatment period.
Results.
No treatment-related changes in mortalities, clinical signs, body weight, gross finding, and organ weight change were detected after 14 days of oral MO extract administration.
In addition, no meaningful MO extract treatment-related changes were observed in the hematological, serum biochemical, and histopathological parameters compared with the normal control group following treatment with doses of up to 450 mg/kg/day.
Conclusion.
Based on these findings, we concluded that treatment of mice with the water extract of MO did not result in significant toxicity and, therefore, it could be considered safe for further pharmacological studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Hye-Sun& Seo, Yun-Soo& Ryu, Seung Mok& Moon, Byeong Cheol& Choi, Goya& Kim, Joong-Sun. 2019. Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1150394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Hye-Sun…[et al.]. Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1150394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Hye-Sun& Seo, Yun-Soo& Ryu, Seung Mok& Moon, Byeong Cheol& Choi, Goya& Kim, Joong-Sun. Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1150394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر