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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection
المؤلفون المشاركون
Daniel, Laurent
Jourde-Chiche, Noémie
Vial, Romain
Zandotti, Christine
Alain, Sophie
Decourt, Alexandre
Purgus, Raj
Bornet, Charleric
Moal, Valérie
Legris, Tristan
المصدر
Case Reports in Transplantation
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation.
Foscarnet is usually proposed when resistance for ganciclovir is suspected, but its use is limited by its nephrotoxicity.
Case Presentation.
We report a case of multiresistant CMV disease in a kidney transplant recipient.
Foscarnet was prescribed after ganciclovir treatment failure in a patient with two mutations in the UL97 viral gene.
Foscarnet induced biopsy-proven kidney crystal precipitation that resulted in severe acute transplant failure and nephrotic syndrome.
Despite a large decrease in immunosuppression, CMV disease was not controlled and a salvage therapy with Brincidofovir (BCV), which is an oral lipid conjugate of cidofovir with limited nephrotoxicity, was attempted.
Clinical and virological remission was observed after a 21-day course of BCV, despite mild and reversible liver toxicity.
However, a new relapse could not be effectively cured by BCV due to a new mutation in the UL54 gene, which is known to confer resistance to cidofovir.
A new course of foscarnet finally resulted in prolonged CMV remission.
Herein, we present a review of foscarnet nephropathy cases in solid-organ transplanted patients.
Conclusions.
This unique case highlights the potential benefit of BCV use during resistant CMV infection, although mutations in the UL54 gene may limit its therapeutic efficacy.
These findings need to be confirmed in clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vial, Romain& Zandotti, Christine& Alain, Sophie& Decourt, Alexandre& Jourde-Chiche, Noémie& Purgus, Raj…[et al.]. 2017. Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection. Case Reports in Transplantation،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vial, Romain…[et al.]. Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection. Case Reports in Transplantation No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1150415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vial, Romain& Zandotti, Christine& Alain, Sophie& Decourt, Alexandre& Jourde-Chiche, Noémie& Purgus, Raj…[et al.]. Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection. Case Reports in Transplantation. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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