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Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis
المؤلفون المشاركون
Park, Jinbong
Youn, Dong-Hyun
Um, Jae-Young
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Benign prostatic hyperplasia (BPH) is a common disease in elderly men which can be characterized by an abnormal enlargement of the prostate associated with lower urinary symptoms.
Current medications available for BPH treatment display several adverse effects; thus, the search for effective treatments with less side effects is still ongoing.
In this study, we investigated the effect of Aconiti Lateralis Radix Preparata (dried root of Aconitum carmichaelii Debx.; AL), which is an herb used to treat extremely cold symptoms in traditional Korean medicine, on BPH using a testosterone propionate- (TP-) induced BPH rat model.
Eight-week inguinal injection of TP induced BPH in rats, the prostate of which was displaying an abnormal proliferation.
The pathological proliferation of the prostate was ameliorated by AL treatment of 4 weeks.
Pathohistological changes in the prostate including epithelial thickness and lumen area were restored in AL-treated rats.
Furthermore, 5α-reductase (5AR) and androgen receptor (AR), the two main factors in the pathogenesis of BPH, were decreased.
In addition, the ratio of BAX and Bcl-2, an indicator of apoptosis, was increased by AL as well.
Similar results were observed in AL-treated LNCaP prostate cancer cells.
AL treatment suppressed the expression of the 5AR-AR axis and increased the ratio of BAX and Bcl-2.
Apoptosis in the testis is considered a crucial side effect of finasteride, a 5AR inhibitor used to treat BPH.
Our results showed that AL treatment did not display such effects, while finasteride treatment resulted in loss of spermatogenic cells within the prostate.
Overall, these results suggest AL as a potentially safe nature-derived therapeutic agent for BPH treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Jinbong& Youn, Dong-Hyun& Um, Jae-Young. 2019. Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150469
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Jinbong…[et al.]. Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1150469
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Jinbong& Youn, Dong-Hyun& Um, Jae-Young. Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1150469
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150469
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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