![](/images/graphics-bg.png)
Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition
المؤلف
المصدر
Case Reports in Veterinary Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-08
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism.
NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin and glutathione and drives the mevalonate pathway that powers many of the basic mechanisms by which cancer cells escape host control.
G6PD is thus a target for cancer treatment being addressed by many groups around the world.
We have discovered that systemic inhibition of G6PD by high dose dehydroepiandrosterone (DHEA) causes a severe autoinflammatory response in dogs, which does not occur in mice or rats.
Since dogs more closely model the human adrenal androgen system than do common laboratory animals, this finding is relevant to the design of G6PD-inhibiting drugs for humans.
The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues.
In a manner comparable to animal models of MKD, the reconstitution of protein geranylgeranylation blocked the autoinflammatory reaction caused by systemic G6PD inhibition.
This autoinflammatory response to systemic G6PD inhibition represents an unexpected result that must be taken into consideration when targeting this oncoprotein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nyce, Jonathan W.. 2017. Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition. Case Reports in Veterinary Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1150731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nyce, Jonathan W.. Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition. Case Reports in Veterinary Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1150731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nyce, Jonathan W.. Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition. Case Reports in Veterinary Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1150731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)