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Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil
المؤلفون المشاركون
Qodriyah, Hj Mohd Saad
Jantan, Ibrahim
Buang, Fhataheya
Ahmad Nazri, Khuzaidatul Azidah
Fauzi, Norsyahida Mohd
Husain, Khairana
Jubri, Zakiah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-23
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Gynura procumbens (Lour.) Merr.
(GP) has been reported in previous studies to possess antihyperlipidaemic, antioxidative, and cardioprotective properties.
This study was aimed to determine the effect of standardised 80% ethanol extract of GP on lipid profiles and oxidative status of hypercholesterolemic rats.
Postmenopausal (PM) Sprague-Dawley rats were ovariectomised and fed with 2% cholesterol diet fortified with five times heated palm oil to develop hyperlipidaemia status.
Two doses of the extract (250 and 500 mg/kg) and atorvastatin (10 mg/kg) were administered once daily via oral gavage for 24 weeks.
Systolic blood pressure (SBP) was increased during the first month in the postmenopausal group and decreased with GP supplementation.
Lipid droplets accumulation was shown at the tunica media (TM) area of the aorta in the postmenopausal group and reduced with GP supplementation.
Total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL), and malondialdehyde (MDA) levels increased (p<0.05) at 3 and 6 months in the postmenopausal group and were reduced with GP supplementation.
GP also increased high-density lipoprotein (HDL) level in the postmenopausal group.
Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were reduced in the postmenopausal group compared to control in the sham group but increased (p<0.05) with GP supplementation.
The results showed that the higher dose of GP (500 mg/kg) gave better effect.
GP has the ability to reduce oxidative stress and prevent membrane cell damage through antioxidant enzyme activity modification and lipid profile changes in postmenopausal rats related to atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad Nazri, Khuzaidatul Azidah& Fauzi, Norsyahida Mohd& Buang, Fhataheya& Qodriyah, Hj Mohd Saad& Husain, Khairana& Jantan, Ibrahim…[et al.]. 2019. Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150778
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad Nazri, Khuzaidatul Azidah…[et al.]. Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1150778
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad Nazri, Khuzaidatul Azidah& Fauzi, Norsyahida Mohd& Buang, Fhataheya& Qodriyah, Hj Mohd Saad& Husain, Khairana& Jantan, Ibrahim…[et al.]. Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150778
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150778
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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