Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats
المؤلفون المشاركون
Ai-Ming, Wu
Zhao, Yi-Zhou
Huang, Ya
Liu, Keke
Chen, Huiyang
Zhao, Jing
Li, Chunhong
Zhao, Mingjing
Li-Xia, Lou
Zhang, Dong-mei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Qiliqiangxin capsule (QLC), a natural herb recipe with therapeutic effect from China, has been widely used in clinical practice for attenuating cardiac remodeling induced by myocardial infarction (MI).
However, the pharmacological mechanism of QLC on cardiac remodeling after MI is not entirely clear.
The present study aims to investigate the effectiveness and mechanisms of QLC on cardiac remodeling induced by MI in rats.
The animal model was established by permanently ligating the left anterior descending coronary artery in rats.
Subsequently, rats with successful ligation were randomly divided into model group, captopril group, and QLC group.
And the control group was operated upon in parallel except ligation, namely, the sham group.
All rats were treated through the intragastric administration once a day for 4 weeks.
Cardiac hemodynamics was measured after treatment.
Then, the left ventricular mass index (LVMI) was examined.
The pathological changes were observed by HE staining.
The collagen volume fraction (CVF) was detected by Masson trichrome staining.
The apoptosis index was obtained by TUNEL fluorescent staining.
The miR-133a and mRNA of TGF-β1, CTGF, Caspase9, and Caspase3 were examined by real-time PCR.
The protein expressions of TGF-β1, CTGF, Caspase9, Caspase3, and cleaved-Caspase3 were tested by Western blot.
Compared with the model group, QLC partially improved cardiac hemodynamics and decreased LVMI.
miR-133a was significantly increased in QLC group.
In addition, QLC declined CVF by downregulating TGF-β1 rather than CTGF.
Meanwhile, QLC decreased the apoptosis index by attenuating Caspase9, Caspase3, and cleaved-Caspase3.
This study suggested that QLC could improve cardiac function and partially attenuate cardiac remodeling by attenuating fibrosis and decreasing apoptosis, which might be partially related to miR-133a, TGF-β1, Caspase9, and Caspase3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Huiyang& Li-Xia, Lou& Zhang, Dong-mei& Zhao, Yi-Zhou& Zhao, Jing& Li, Chunhong…[et al.]. 2019. Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Huiyang…[et al.]. Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Huiyang& Li-Xia, Lou& Zhang, Dong-mei& Zhao, Yi-Zhou& Zhao, Jing& Li, Chunhong…[et al.]. Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر