The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics

المؤلفون المشاركون

Sheau Chin, Lim
Ibrahim, Baharudin
Amin, Arwa M.
Azri Mohamed Noor, Dzul
SK Abdul Kader, Muhamad Ali
Kah Hay, Yuen

المصدر

Cardiology Research and Practice

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-03-21

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأمراض

الملخص EN

Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention.

However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular events.

Although many genetic and nongenetic factors are known, great portion of clopidogrel variable platelets reactivity remain unexplained which challenges the personalization of clopidogrel therapy.

Current methods for clopidogrel personalization include CYP2C19 genotyping, pharmacokinetics, and platelets function testing.

However, these methods lack precise prediction of clopidogrel outcome, often leading to insufficient prediction.

Pharmacometabolomics which is an approach to identify novel biomarkers of drug response or toxicity in biofluids has been investigated to predict drug response.

The advantage of pharmacometabolomics is that it does not only predict the response but also provide extensive information on the metabolic pathways implicated with the response.

Integrating pharmacogenetics with pharmacometabolomics can give insight on unknown genetic and nongenetic factors associated with the response.

This review aimed to review the literature on factors associated with the variable platelets reactivity response to clopidogrel, as well as appraising current methods for the personalization of clopidogrel therapy.

We also aimed to review the literature on using pharmacometabolomics approach to predict drug response, as well as discussing the plausibility of using it to predict clopidogrel outcome.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Amin, Arwa M.& Sheau Chin, Lim& Azri Mohamed Noor, Dzul& SK Abdul Kader, Muhamad Ali& Kah Hay, Yuen& Ibrahim, Baharudin. 2017. The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiology Research and Practice،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1150987

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Amin, Arwa M.…[et al.]. The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiology Research and Practice No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1150987

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Amin, Arwa M.& Sheau Chin, Lim& Azri Mohamed Noor, Dzul& SK Abdul Kader, Muhamad Ali& Kah Hay, Yuen& Ibrahim, Baharudin. The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1150987

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1150987