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Efficacy and Safety of Safflower Yellow in Early Diabetic Nephropathy: A Meta-Analysis
المؤلفون المشاركون
Jin, Xiuze
Shi, Liuyan
Chang, Feng
Lu, Yun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Diabetic nephropathy (DN) is a major cause of end-stage renal disease.
In order to palliate renal function impairment and reduce kidney related mortality, it is crucial to treating DN patients at the early stage.
This study aims to assess the efficacy and safety of conventional therapy combined with safflower yellow versus conventional therapy alone in early DN patients.
Methods.
A meta-analysis of randomized controlled trials that compared safflower yellow plus conventional therapy with conventional therapy alone in early DN patients was conducted.
Papers were searched using the electronic databases and reference lists.
Two reviewers working independently extracted relevant data and carried out risk-of-bias assessments.
Statistical analysis was undertaken in Review Manager 5.3.
Results.
Fourteen trials (1,072 patients) were included in the meta-analysis.
Conventional therapy combined with safflower yellow was associated with a higher effective rate (RD, 0.24; 95% CI, 0.17 to 0.30) and a greater decline in urinary albumin excretion rates (SMD, -1.34; 95% CI, -1.77 to -0.92), fasting blood glucose (MD, -0.57; 95% CI, -0.98 to -0.16), serum creatinine (MD, -12.36; 95% CI, -14.66 to -10.06), and blood urea nitrogen (SMD, -0.93; 95% CI, -1.13 to -0.73) in the subgroup with a follow-up time > 15 days.
The incidence of adverse events did not differ significantly between these two regimens (RD, -0.01; 95% CI, -0.03 to 0.01).
Findings were similar in the subgroup with a follow-up time < 15 days.
Conclusions.
Conventional therapy combined with safflower yellow had a more beneficial effect than conventional therapy alone in early DN patients.
There were significant differences in effective rate, urinary albumin excretion rates, fasting blood glucose, serum creatinine, and blood urea nitrogen between the two regimens and no significant difference in adverse events.
More randomized controlled research using standardized protocols would be needed in the future to compare these two regimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Xiuze& Shi, Liuyan& Chang, Feng& Lu, Yun. 2019. Efficacy and Safety of Safflower Yellow in Early Diabetic Nephropathy: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151099
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Xiuze…[et al.]. Efficacy and Safety of Safflower Yellow in Early Diabetic Nephropathy: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151099
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Xiuze& Shi, Liuyan& Chang, Feng& Lu, Yun. Efficacy and Safety of Safflower Yellow in Early Diabetic Nephropathy: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151099
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151099
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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