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Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model
المؤلفون المشاركون
Hammeso, Workineh Woldeselassie
Emiru, Yohannes Kelifa
Ayalew Getahun, Kefyalew
Kahaliw, Wubayehu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Diabetes mellitus has become a major public health and economic problem across the globe.
The inadequacies, as well as serious adverse effects associated with conventional medicines, led to a determined search for alternative natural therapeutic agents.
The leaf latex extract of Aloe megalacantha has been used for the management of diabetes mellitus in Ethiopian folk medicine.
This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of the leaf latex extract of A.
megalacantha in streptozotocin- (STZ-) induced diabetic model.
Methods.
The experimental diabetes was induced in Swiss albino mice by the administration of a single dose of STZ (150 mg/kg), intraperitoneally.
The leaf latex extract of A.
megalacantha at three different doses (100, 200, and 400 mg/kg) was administered for a period of 14 days.
Fasting blood glucose levels (BGLs) were measured by glucose-oxidase and peroxidase reactive strips.
After fourteen days, mice from all groups fasted and the blood was collected through puncturing the retroorbit of the eyes under mild anesthetic condition.
The collected blood sample was used to determine serum biochemical parameters such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) cholesterol.
The statistical analysis of results was carried out using one-way analysis (ANOVA) followed by post hoc multiple comparison tests.
Results.
Oral administration of A.
megalacantha leaf latex extract at doses of 100, 200, and 400 mg/kg daily for 14 days results in a significant (p < 0.05) decrease in fasting BGL as compared to negative control STZ-induced diabetic mice.
The leaf latex has significantly reduced the level of TC, TG, and LDL, VLDL cholesterol while a significant (p < 0.05) HDL cholesterol increment was observed.
Conclusions.
The findings of the present investigation indicated that the leaf latex of A.
megalacantha possessed significant antihyperglycemic and antihyperlipidemic potential which may prove the claimed use of the plant in amelioration of diabetes and associated complications in Ethiopian folk medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hammeso, Workineh Woldeselassie& Emiru, Yohannes Kelifa& Ayalew Getahun, Kefyalew& Kahaliw, Wubayehu. 2019. Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hammeso, Workineh Woldeselassie…[et al.]. Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hammeso, Workineh Woldeselassie& Emiru, Yohannes Kelifa& Ayalew Getahun, Kefyalew& Kahaliw, Wubayehu. Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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