Lupus and NMOSD: The Blending of Humoral Autoimmunity
المؤلفون المشاركون
Ochi, Maria Goretti S.
Shapiro, Samantha C.
Melamed, Esther
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Systemic lupus erythematous (SLE) is a chronic autoimmune disease that can target any organ of the body.
It may coexist with other autoimmune neurologic conditions such as neuromyelitis optica spectrum disorder (NMOSD).
NMOSD, previously known as Devic’s disease, is an autoimmune inflammatory disorder of the central nervous system (CNS) that targets the spinal cord, optic nerves, and certain brain regions.
Most current evidence suggests that NMOSD is best described as a CNS astrocytopathy.
While these diseases share several immunosuppressive treatment options, timely diagnosis of NMOSD is critical as patients may benefit from treatment tailored specifically to NMOSD as opposed to SLE.
Steroids, plasmapheresis, intravenous immunoglobulin, cyclophosphamide, azathioprine, mycophenolate mofetil, and rituximab are used to treat both SLE and NMOSD.
However, there are several new therapies (inebilizumab, eculizumab, and satralizumab) recently approved specifically for use in NMOSD.
In this case series, we report on three patients with coexisting SLE and NMOSD.
We describe a 31-year-old woman who suffered an NMOSD flare after 11 years of clinical remission in the context of receiving an influenza vaccination; her SLE remained quiescent on hydroxychloroquine.
Next, we describe a 52-year-old woman with emergence of neurologically devastating seropositive NMOSD in the setting of active treatment for SLE with intravenous cyclophosphamide, oral steroids, and hydroxychloroquine.
Last, we describe a 48-year-old woman with emergence of seronegative NMOSD in the setting of SLE that was well-controlled on azathioprine and hydroxychloroquine.
These cases illustrate the importance of accurate diagnosis and targeted treatment of NMOSD when coexisting with SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ochi, Maria Goretti S.& Shapiro, Samantha C.& Melamed, Esther. 2020. Lupus and NMOSD: The Blending of Humoral Autoimmunity. Case Reports in Rheumatology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1151205
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ochi, Maria Goretti S.…[et al.]. Lupus and NMOSD: The Blending of Humoral Autoimmunity. Case Reports in Rheumatology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1151205
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ochi, Maria Goretti S.& Shapiro, Samantha C.& Melamed, Esther. Lupus and NMOSD: The Blending of Humoral Autoimmunity. Case Reports in Rheumatology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1151205
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151205
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر